Anti-Integrin aM clone ICRF44, this week's featured reagent, has recently been featured in a Journal of Immunology paper jointly authored by groups at the University of Gothenburg and Università di Genova. The study extends the role of neutrophils in immunity and suggests that TLR-driven cross talk between neutrophils and NK cells may play a key role in initiating the adaptive immune response.
Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. The alpha M beta 2 integrin is important in the adherence of neutrophils and monocytes to stimulated endothelium and also in the phagocytosis of complement coated particles. Clone ICRF44 was raised against rheumatoid synovial cells and human monocytes and therefore has reactivity in human and primate samples. It is a versatile antibody having applications in FACS analysis, immunohistochemistry, immunoprecipitation and western blots.
Clone ICRF44 was developed at Cancer Research UK's London Research Institute by Professor Nancy Hogg. Professor Hogg has made a significant contribution to the field of cell surface biology. In the early seventies it was Nancy who discovered the fibronectin protein and observed its disappearance when cells become cancerous. Professor Hogg ran the Leukocyte Adhesion Laboratory at the London Research Institute from 1982 to her retirement in 2011. in 2002, she was elected to the Fellowship of the Academy of Medical Sciences for her distinguished contributions to the field of leukocyte biology.
HAVE YOU REGISTERED?
Join the ever-growing global Ximbio community. Register and receive updates about new reagents, institutes and new features being added to the website.