We're pleased to send you our fifth Ximbio product update. This month’s update focuses on newly developed antibodies from the University of Manchester, Cancer Research UK Manchester Institute and the Hospital for Special Surgery in the USA.
Ximbio is pleased to introduce 22 new antibodies available for licence as hybridomas or purchase as antibodies for commercial resale.
For licensing and sales enquiries please email: enquiries@ximbio.com
Or call +44 (0)20 3469 6449.
Technical datasheets for Ximbio’s expanding research tool portfolio can be accessed at www.ximbio.com
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PMIDs: 20376365, 14576347, 12003637
The human 5T4 oncofoetal antigen is a highly glycosylated protein expressed by trophoblast and a few specialized adult epithelia. Up-regulation of 5T4 expression in some cancers is associated with poor clinical outcome; overexpression of human 5T4 cDNA in epithelial cells can alter their morphology and motility, supporting a role for such functions in cancer and development. |
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PMID [9HU]: 8647900PMIDs [9MO]: 19273593, 16230393, 9920899, 8647900
ADAM9 encodes disintegrin and metalloprotease (ADAM) domain 9, which is a member of the ADAM protein family. Members of this family are membrane- anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biologic processes involving cell- cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. |
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ADAM12 is involved in skeletal muscle regeneration, specifically at the onset of cell fusion. ADAM12 is also involved in macrophage-derived giant cells and osteoclast formation from mononuclear precursors.
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PMIDs: 12897135, 8617717
ADAM15 is an active metalloproteinase with gelatinolytic and collagenolytic activity which plays a role in the wound healing process. ADAM family members are type I transmembrane glycoproteins known to be involved in cell adhesion and proteolytic ectodomain processing of cytokines and adhesion molecules.
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Applications: WB
Reactivity: Mouse PMIDs: 12897135, 9748307, 19207106, 19487280
ADAM15 is an active metalloproteinase with gelatinolytic and collagenolytic activity which plays a role in the wound healing process. ADAM family members are type I transmembrane glycoproteins known to be involved in cell adhesion and proteolytic ectodomain processing of cytokines and adhesion molecules. |
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PMIDs: 17709479, 20980382, 21407195, 10727411, 12207026
ADAM17 (TACE/CD156b) has proved capable of cleaving epidermal growth factor receptor (EGFR) ligands, extracellular Notch1, cell-surface receptors, and adhesion molecules. As proteolytic cleavage is an indispensable activation event for many of these substrates, ADAM17 has emerged as an attractive therapeutic target for the treatment of cancer and rheumatoid arthritis. |
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Anti-ADAM19, Polyclonal [19MOCYT]
Applications: WB
Reactivity: Mouse PMIDs: 12682046, 9461614, 17344430, 14673146
ADAM19, is a member of the ADAM (a disintegrin and metalloprotease-like domain) family. ADAM19 was first described in muscle cells as a protein with homology to the fertilins (ADAMs 1 and 2). |
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Applications: WB
Reactivity: Mouse PMID: 10794709
ADAM28, also known as eMDCII, MDC-Ls and TECADAM, was first described in lymphocytes, also in Thymic Endothelial Cells (TECADAM), as well as in the epididymus. Later works describe two forms of ADAM28: ADAM28-S and ADAM28-L (short and long forms). |
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PMID: 10531379
Sorting nexin-9 (SNX9) is involved in endocytosis and intracellular vesicle trafficking, both during interphase and at the end of mitosis. SNX9 is required for efficient progress through mitosis and cytokinesis. |
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PMIDs: 19668337, 18845630, 17971775, 15769846, 12134161
CD29 is a member of the family of integrins, membrane receptors involved in cell adhesion and recognition in a variety of processes including embryogenesis, hemostasis, tissue repair, immune response and metastatic diffusion of tumor cells.
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PPMIDs: 25322916, 25239826, 10947963, 10036233, 9931299
Reactivity: Human
CD49b is an integrin alpha subunit which makes up half of the α2β1 integrin duplex. Integrins are heterodimeric integral membrane glycoproteins composed of a distinct alpha chain and a common beta chain.
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Anti-CD151 [11G5a]
Applications: IHC WB ELISA FACS IHC IF IP WB
Reactivity: Human
PMIDs: 21961047, 21320503, 20937830, 20715158, 20578262
Clone 11G5a recognizes the human CD151 cell surface antigen, also known as PETA-3. CD151 is expressed by epithelial cells, endothelial cells, platelets, megakaryocytes, monocytes and in the renal glomeruli and proximal and distal tubules. CD151 is not expressed by lymphocytes or granulocytes. More recently CD151 has also been shown to be expressed by erythrocytes, and to carry the MER2 blood group antigen.
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Reactivity: Human
PMIDs: 22923148, 22552543, 20514404, 19148540, 18949377
CD49b also known as integrin alpha-2, VLA-2 subunit alpha or collogen receptor. CD49b is a 1181 amino acid ¦130 kDa single pass type-1 transmembrane glycoprotein which forms a heterodimer with integrin beta-1 and mediates the adhesion of platelets and other cell types to the extracellular matrix.
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Reactivity: Human
PMIDs: 19175293, 15615773 – SNAKA51
PMIDs: 15615773, 12615914, 10567237 – SNAKA52
CD49e is the integrin alpha 5 chain. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain.
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Reactivity: Human
PMIDs: 21511727, 18417711, 15557320
Integrin beta1 (CD29) is a transmembrane glycoprotein that forms noncovalent complexes with various alpha integrin subunits to form the functional receptors that bind to specific extracellular matrix proteins. Integrin receptors are involved in cell adhesion and recognition in a variety of processes including embryogenesis, hemostasis, tissue repair, immune response and metatastatic diffusion of tumor cells.
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