New Antibodies from Ximbio

Please find below our fourteenth Ximbio product update. This month’s mailer details fourteen new monoclonal antibodies and one new polyclonal antibody developed at Cancer Research UK’s Clare Hall and Lincoln's Inn Fields laboratories, Imperial College, Queen Mary University of London, University College London, the University of Georgia and Vertebrate Antibodies for licence or purchase.
 
For licensing and sales enquiries please email: enquiries@ximbio.com

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Technical datasheets for Ximbio’s expanding research tool portfolio can be accessed at www.ximbio.com

	Anti-XPF [4H4] Applications: ELISA IF WB Reactivity: Human PMID: 19723666 Nucleotide excision repair (NER) is a DNA repair pathway that removes lesions induced by a variety of agents such as UV irradiation. ERCC1 and XPF form the heterodimer ERCC1-XPF, forming a DNA endonuclease that is essential for the dual incision step of NER (cleaves 5' of the DNA lesion)..
	Anti-C3 [WM1] Applications: Fn IP Reactivity: Human PMID: 6163641 C3 plays a central role in the activation of the complement system. Its processing by C3 convertase is the central reaction in both classical and alternative complement pathways.
	Anti-p53 [PAb242] Applications: IHC WB ELISA IHC IF IP Reactivity: Mouse PMIDs: 26508747, 8649788, 2426467 p53 is a stress-regulated transcription factor that regulates cell cycle arrest and was first identified as an SV40 large T antigen-binding protein. Antibody has specific utility in mouse; especially as an immunohistochemical reagent
	Anti-Keratin1 (Ha1) [LHTric-1] Applications: IHC WB IHC WB Reactivity: Human Rat PMIDs: 10651700, 9274621 LHTric-1 is specific to the acidic hair-type keratin Ha1. Ha1 is one of the major hard keratins found in nail.
	Anti-HPV16E2, Polyclonal [HPV16E2] Applications: IHC WB Reactivity: Human PMIDs: 26474276, 20530671 A novel and important role for the HPV16-E2 protein in controlling host cell cycle during malignant transformation was recently revealed. Cells expressing HPV16-E2 in vitro were arrested in prophase alongside activation of a sustained DDR signal.
	Anti-CHIKV [11E7], [6A11], [8A2c] & [3E7b] Applications: ELISA IHC Fn WB Reactivity: Virus PMID: 26305993 Chikungunya virus (CHIKV) is known to be transmitted to humans by mosquito vectors, primarily Aedes aegypti and A. albopictus.
	Anti-Factor VIII:c heavy chain [RFF-VIII:c/10] Applications IF WB Reactivity: Human PMIDs: 3937279, 2413885, 6403638 The commonest severe congenital bleeding disorder in all races is haemophilia A. The characteristic defect is a lack of coagulation factor VIII:C. Factor VIII:C is a glycoprotein that functions as a cofactor for factor IXa which, in the presence of calcium and phospholipids, converts factor X to the activated form Xa.
	Anti-Actin11 (M1)  [mAb2345a] Applications: IF WB Reactivity: Arabidopsis PMIDs: 22589468, 11449050, 10417720 Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.
	Anti-Actin8 [mAbGPa] Applications: IF WB Reactivity: Arabidopsis PMIDs: 22589468, 11449050, 10417720 Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.
	Anti-Actin2 [mAb13a] Applications: IF WB Reactivity: Arabidopsis PMIDs: 22589468, 11449050, 10417720 Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.
	Anti-Actin1 [mAb45a] Applications: IF WB Reactivity: Arabidopsis PMIDs: 22589468, 11449050, 10417720 Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.
	Anti-CEACAM19 [Z5P2D9*A9] Applications: ELISA WB Reactivity: Human CEACAM19 belongs to the carcinoembryonic antigen (CEA) gene family. In humans, this family of proteins are involved in several key biological processes such as cell adhesion, cell growth and differentiation, cellular recognition, apoptosis and angiogenesis. Recent studies have shown that CEACAM19 is upregulated, at the mRNA level, in ovarian and breast cancer.