New Antibodies from Ximbio

CD45 (leucocyte common antigen) is a receptor-linked protein tyrosine phosphatase that is expressed on all leucocytes, and plays a crucial role in the function of these cells.

CEACAM3/5 belong to the immunoglobulin superfamily. The proteins contains 1 Ig-like V-type (immunoglobulin-like) domain and the cytosolic domain is involved in S100A9 interaction. Tyrosine-phosphorylated in response to microbial binding. Tyr-230 and Tyr-241 are both required for phosphorylation to be detected.

CEACAM6 is a glycosyl phosphatidyl inositol (GPI) linked glycoprotein. CEACAM6 expression is upregulated in many adenocarcinomas and leukemias. CEACAM6 is expressed in epithelial cells of the fetal and adult gastrointestinal tract, epithelia of glandular tissues, squamous epithelial cell of the tongue, esophagus and cervix as well as on granulocytes.

CEACAM8 is a glycosylphosphatidylinositol (GPI)-linked protein also known as CD67, CGM6, and NCA-95. CEACAM8 is a member of the immunoglobulin superfamily, carcinoembryonic antigen (CEA)-like subfamily. CEACAM8, expressed on granulocytes, has been reported to induce activation in neutrophils and to be involved in heterophilic adhesion with CEACAM6.

CEACAM5 is a glycoprotein involved in cell adhesion and intracellular signaling. It is normally produced during fetal development in the gut, and its production stops before birth. CEA is re-expressed in increased amounts in Intestinal Carcinomas and several other tumors.

Applications: ELISA FACS IF IP WB

CEACAM5/6/8 are glycoproteins involved in cell adhesion and intracellular signaling. They are normally produced during fetal development in the gut, and their production stops before birth. CEA is re-expressed in increased amounts in Intestinal Carcinomas and several other tumors.

CEACAM19 belongs to the carcinoembryonic antigen (CEA) gene family. In humans, this family of proteins are involved in several key biological processes such as cell adhesion, cell growth and differentiation, cellular recognition, apoptosis and angiogenesis. Recent studies have shown that CEACAM19 is upregulated, at the mRNA level, in ovarian and breast cancer.

Bovine tuberculosis (TB) caused by Mycobacterium bovis continues to be a significant animal health issue in some countries, including the United Kingdom and Ireland. Anti-Mycobacterium bovis [11G3] has been demonstrated to work by ELISA and for immunocapture.

Mycobacterium avium subsp. paratuberculosis (MAP) is the causative agent for Johne’s disease, a highly-infectious wasting disease that affects a range of domestic ruminants including cattle, sheep, goats and deer. Anti-Mycobacterium avium subsp. paratuberculosis [15D10] has a high degree of specificity and has been demonstrated to work by ELISA and for immunocapture.

 

The genus Listeria comprises six species: L. monocytogenes, L. innocua, L. welshimeri, L. seeligeri, L. ivanovii and L. grayi. Listeria monocytogenes, the most commonly isolated pathogenic member, is associated with a wide spectrum of human and animal diseases. In the smear from the original tissue, L. monocytogenes may appear as gram-positive coccobacilli that may be confused with Streptococcus agalactiae (group B), enterococci, or Corynebacterium spp. Listeria is differentiated from streptococci by a positive catalase test. L. monocytogenes is the only species of the genus Listeria that has been clearly documented as a pathogen for humans.