New Antibodies from Ximbio

Please find below our seventh Ximbio product update. This month’s mailer details monoclonal and recombinant antibodies new to Ximbio developed at the CRUK London Research Institute, the University of Cambridge, the University of Manchester, Absolute Antibody and Vertebrate Antibodies.

Ximbio introduces 17 new monoclonal antibodies available for licence or purchase and 2 new recombinant antibodies available for purchase.
 
For licensing and sales enquiries please email: enquiries@ximbio.com

Or call +44 (0)20 3469 6449.

Technical datasheets for Ximbio’s expanding research tool portfolio can be accessed atwww.ximbio.com

	Anti-APC11 [CRQ1.1] Applications: WB Reactivity: Human PMID: 23288039 APC11 is the catalytic subunit of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle.
	Anti-PLA2R [12-6-5] Applications: ELISA FACS IHC IF WB Reactivity: Human PMIDs: Summer 2016 PLA2R is the major auto-antigen in the autoimmune kidney disease, membranous nephropathy. Detection of PLA2R antigen by IHC in the immune complexes present in the glomerular basement membrane is used as a diagnostic marker for the disease.  PLA2R acts a tumour suppressor protein and it is associated with cell senescence and differentiated cells.
	Anti-Collagen Type VII [LH7.2] Applications: ELISA IHC IF WB PMIDs: 21939396, 20637030, 11348454, 2354110 Reactivity: Human Type VII Collagen is found in anchoring fibrils at the dermal-epidermal junction. Type VII collagen is defective in Recessive Dystrophic Epidemolysis Bullosa (RDEB). LH7.2 can be used for differentiating invasive from non-invasive melanoma through clear visualisation of appearance and integrity of epidermal basement membrane and diagnosis and antenatal diagnosis of RDEB.
	Anti-Melanoma [LHM3] Applications: IHC IF IP WB Reactivity: Human PMIDs: 8589614 LHM3 can be used in a diagnostic panel for immunopathology of malignant melanoma. Potential candidate for immunoimaging and immunotherapy of disseminated melanoma.
	Anti-B lymphocytes [UCH-B1] Applications: FACS IHC Reactivity: Human PMID: 3257923 UCH-B1 antigen (85kD) is detected on a sub-population of B lymphocytes, probably related to stage of activation or maturation. UCH-B1 may be useful for differential diagnosis of B cell leukaemias and as a marker of prolymphocytic leukaemia.
	Anti-cMyc [PM3E7] Applications:IHC IP WB Reactivity: Human The c-Myc and N-Myc oncogenes are members of the Myc family of transcription factors that regulate cell proliferation and apoptosis. c-Myc is expressed in proliferating tissues and increased c-Myc expression is found in many cancers. N-Myc is amplified in a proportion of neuroblastoma patients.
	Anti-SARS Nucleocaspid [6H3] Applications: IF WB Reactivity: Virus Severe acute respiratory syndrome coronavirus (SARS-CoV) genome encodes for four major structural proteins, namely nucleocaspid (N), spike (S), membrane (M) and envelope (E).
	Anti-CXCL16 [4.4] Applications: IF WB Reactivity: Human CXCL16, a newly discovered CXC chemokine, exists both in a transmembrane and a soluble form. The membrane bound chemokine act as a ligand for CXC chemokine receptor (CXCR) 6 which is expressed by peripheral blood leukocytes.
	Anti-CD3, Recombinant [UCH-T1] Applications: FACS WB Reactivity: Human Original hybridoma first published in PMID 6788570. Anti-CD3, Recombinant [UCH-T1] is a recombinantly produced version of the popular anti-CD3 mouse monoclonal.
	Anti-Listeria monocytogenes antigen 2 [2:13 C5] & [2:4 E10] Applications: ELISA WB Reactivity: L. monocytogenes Listeria monocytogenes, the most commonly isolated pathogenic member, is associated with a wide spectrum of human and animal diseases.
	Anti-ERO1-Like Alpha [V23P3C9*H2] Applications: ELISA IHC WB Reactivity: Dog, Horse, Human, Mouse, Pig, Rat, Sheep. ERO1-Like Alpha is thought to be an oxidoreductase involved in disulfide bond formation in the endoplasmic reticulum.
	Anti-Syndecan 4 [V60P2C2*F2] Applications: ELISA IHC WB Reactivity: Human Syndecan 4 is a transmembrane (type I) heparan sulfate proteoglycan that functions as a receptor in intracellular signaling. It is found as a homodimer and is a member of the syndecan proteoglycan family.
	Anti-LAMP3 [L3P2H10*E3] Applications: ELISA WB IHC Reactivity: Human Expressed in lymphoid organs and dendritic cells. Expressed in lung. Up-regulated in carcinomas of the esophagus, colon, rectum, ureter, stomach, breast, fallopian tube, thyroid and parotid tissues.
	Anti-BOP1 [T7-P1B7*A8] Applications: ELISA IHC WB Reactivity: L. monocytogenes BOP1 is a component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome.
	Anti-TNFRSF18 (cell membrane form) [T9P4G4*D7] Applications: ELISA IHC WB Reactivity: Human TNFRSF18 is the receptor for TNFSF18. It seems to be involved in interactions between activated T-lymphocytes and endothelial cells and in the regulation of T-cell receptor-mediated cell death.