- Datasheet
- References (6)
- Inventor Info
Info
| Catalogue Number | 153989 |
| Applications | IP WB |
| Antigen/Gene or Protein Targets | Tristetraprolin |
| Synonyms | TTP, ZFP36 Ring Finger Protein, Growth Factor-Inducible Nuclear Protein NUP475 G0/G1 Switch Regulatory Protein 24, RNF162A, Zfp-36, NUP475, G0S24, TIS11 |
| Reactivity | Human and Mouse |
| Relevance | Members of the tristetraprolin (TTP) family of RNA binding proteins can bind to adenine/uridine-rich elements (AREs) in the 3’-untranslated regions (3’UTRs) of specific mRNAs, and then promote their turnover. For example, TTP is a component of a negative feedback loop that interferes with TNF-alpha production by destabilizing its mRNA. TTP has been shown to interact with 14-3-3 protein family members, such as YWHAH, and with NUP214, a member of the nuclear pore complex. Mice deficient in TTP develop a complex syndrome of inflammatory diseases. |
| Host | Rabbit |
| Immunogen | 34 C-terminal amino acids of TTP fused to GST |
| Molecular Weight (kDa) | 36 kDa |
| Research Area | Cell Signaling & Signal Transduction, Gene Expression, Immunology |
References: 6 entries
Sedlyarov et al. 2016. Mol Syst Biol. 12(5):868. PMID: 27178967.
Tristetraprolin binding site atlas in the macrophage transcriptome reveals a switch for inflammation resolution.
Europe PMC ID: 27178967
Kratochvill et al. 2011. Mol Syst Biol. 7:560. PMID: 22186734.
Tristetraprolin-driven regulatory circuit controls quality and timing of mRNA decay in inflammation.
Europe PMC ID: 22186734
Schaljo et al. 2009. J Immunol. 183(2):1197-206. PMID: 19542371.
Tristetraprolin is required for full anti-inflammatory response of murine macrophages to IL-10.
Europe PMC ID: 19542371
Add a reference
References: 6 entries
Sedlyarov et al. 2016. Mol Syst Biol. 12(5):868. PMID: 27178967.
Tristetraprolin binding site atlas in the macrophage transcriptome reveals a switch for inflammation resolution.
Kratochvill et al. 2011. Mol Syst Biol. 7:560. PMID: 22186734.
Tristetraprolin-driven regulatory circuit controls quality and timing of mRNA decay in inflammation.
Schaljo et al. 2009. J Immunol. 183(2):1197-206. PMID: 19542371.
Tristetraprolin is required for full anti-inflammatory response of murine macrophages to IL-10.
Add a reference
Inventor Information
Inventors
|
Prof Pavel Kovarik |
