Anti-IL21 [V28P5G1*C4]

Tool Details

*FOR RESEARCH USE ONLY (for other uses, please contact the licensing team)

• Name: Anti-IL21 [V28P5G1*C4]
• Alternate name: IL 21 antibody, Interleukin 21 antibody, Interleukin21 antibody
• Research fields: Cancer;Immunology
• Clone: V28P5G1*C4
• Tool sub type: Primary antibody
• Class: Monoclonal
• Conjugation: Unconjugated
• Strain: Balb/c
• Reactivity: Salmon ; Rainbow Trout
• Host: Mouse
• Application: ELISA ; IHC ; WB
• Description: IL21 is a member of the type I cytokine family, which includes IL2 and IL15. IL21 signals through the common gamma-chain and a unique IL21 receptor. The IL21 receptor is expressed in cells lymphoid-lineage and regulates the proliferation and differentiation of T and B lymphocytes. Studies suggest that IL21 is a key component of CD4 T cell help that is required for maintaining the CD8+ T cell responses and inducing B cell antibody response. IL21 also promotes the development of Th17 and Tfh cells, modulates the cytotoxic activity and survival of NK and CD8+ T cells, and suppresses the maturation of dendritic cells. It is also implicated in the development of autoimmune disease and has antitumor activity.
• Immunogen: Ovalbumin-conjugated synthetic peptide- LLQKAISRLA
• Isotype: IgG
• Myeloma used: P3X63Ag8.653
• Recommended controls: Western Blot recombinant IL21; IHC - Formalin-fixed, paraffin-embedded fish head kidney and spleen

Target Details

• Target: Interleukin 21 (IL21)
• Tissue cell line specificity: Western Blot recombinant IL21; IHC - Formalin-fixed, paraffin-embedded fish head kidney and spleen
• Target background: IL21 is a member of the type I cytokine family, which includes IL2 and IL15. IL21 signals through the common gamma-chain and a unique IL21 receptor. The IL21 receptor is expressed in cells lymphoid-lineage and regulates the proliferation and differentiation of T and B lymphocytes. Studies suggest that IL21 is a key component of CD4 T cell help that is required for maintaining the CD8+ T cell responses and inducing B cell antibody response. IL21 also promotes the development of Th17 and Tfh cells, modulates the cytotoxic activity and survival of NK and CD8+ T cells, and suppresses the maturation of dendritic cells. It is also implicated in the development of autoimmune disease and has antitumor activity.

Applications

• Application: ELISA ; IHC ; WB

Handling

• Format: Liquid
• Concentration: 0.9-1.1 mg/ml
• Unit size: 100 ug
• Storage buffer: PBS with 0.02% azide
• Storage conditions: -15° C to -25° C
• Shipping conditions: Dry ice