Anti-CD45R [351C5]
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- Datasheet
- References (6)
- Inventor Info
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| Catalogue Number | 151047 |
| Applications | FACS IHC IF IP WB |
| Antigen/Gene or Protein Targets | Protein tyrosine phosphatase, receptor type, C (PTPRC, CD45R) |
| Synonyms | Protein Tyrosine Phosphatase; Receptor Type C; CD45 Antigen; CD45; L-CA; T200; Protein Tyrosine Phosphatase; Receptor Type; C Polypeptide; T200 Leukocyte Common Antigen; T200 Glycoprotein; EC 3.1.3.48; GP180; CD45R; B220; LCA; LY5 |
| Reactivity | Human |
| Relevance | PTPRC (CD45) is a transmembrane tyrosine phosphatase that is present on all leukocytes. PTPRC regulates the threshold of T cell antigen receptor (TCR) signaling through dephosphorylation of protein tyrosine kinases (e.g. Lck and Fyn). CD45R and CD45RO are two of multiple PTPRC isoforms generated by alternative splicing. CD45R is found on B lymphocyte and T lymphocyte subsets. CD45RO is present on 50% of T cells, most granulocytes and monocytes and most mature T cell tumours. 351C5 may be used in the typing of leukaemias and lymphomas and in studies of functional subsets of B and T cells. |
| Host | Mouse |
| Immunogen | Raji cells |
| Subclass | IgM |
| Recommended Growing Conditions | DMEM + 5% FCS |
| Research Area | Cancer, Cell Type or Organelle Marker, Cell Signaling & Signal Transduction, Immunology, Stem Cell Biology |
References: 6 entries
Leitenberg et al. 1996. J Exp Med. 183(1):249-59. PMID: 8551228.
The extracellular domain of CD45 controls association with the CD4-T cell receptor complex and the response to antigen-specific stimulation.
Europe PMC ID: 8551228
Trowbridge et al. 1994. Annu Rev Immunol. 12:85-116. PMID: 8011300.
CD45: an emerging role as a protein tyrosine phosphatase required for lymphocyte activation and development.
Europe PMC ID: 8011300
Murray et al. 1985. Clin Exp Immunol. 59(2):315-26. PMID: 3872187.
Two monoclonal antibodies raised against a Burkitt lymphoma cell line recognise different cell types within lymphoid follicles.
Europe PMC ID: 3872187
Add a reference
References: 6 entries
Leitenberg et al. 1996. J Exp Med. 183(1):249-59. PMID: 8551228.
The extracellular domain of CD45 controls association with the CD4-T cell receptor complex and the response to antigen-specific stimulation.
Trowbridge et al. 1994. Annu Rev Immunol. 12:85-116. PMID: 8011300.
CD45: an emerging role as a protein tyrosine phosphatase required for lymphocyte activation and development.
Murray et al. 1985. Clin Exp Immunol. 59(2):315-26. PMID: 3872187.
Two monoclonal antibodies raised against a Burkitt lymphoma cell line recognise different cell types within lymphoid follicles.
Add a reference