Anti-BCRABL [4C12]
Invented at Queen Mary University of London
- Datasheet
- References (6)
- Inventor Info
Info
| Catalogue Number | 151054 |
| Applications | IHC IF RIA |
| Antigen/Gene or Protein Targets | BCRABL |
| Reactivity | Human |
| Relevance | The BCR gene is involved in the 9:22 translocation that generates the Philadelphia chromosome both in chronic myeloid leukemia (CML) and in a proportion of cases of acute lymphocytic leukemia (ALL). A 5' bcr sequence becomes fused to an abl sequence (including tyrosine kinase domain sequences) from chromosome 9 and results in the production of a chimaeric BCR-ABL protein with enhanced kinase activity. These antibodies may be useful for studies of the oncogene and have potential diagnostic and prognostic applications. |
| Host | Mouse |
| Immunogen | BCR-ABL peptide |
| Subclass | IgG1 |
| Myeloma Used | P3X63Ag8.653 |
| Recommended Growing Conditions | DMEM + 5% FCS |
| Strain | Balb/c |
| Notes | Immunocytochemistry/Immunofluorescence 1:40-1:80 |
| Research Area | Cancer, Cell Signaling & Signal Transduction, Epigenetics & Nuclear Signalling |
References: 6 entries
Dhut et al. 1990. Leukemia. 4(11):745-50. PMID: 2232885.
BCR-ABL and BCR proteins: biochemical characterization and localization.
Europe PMC ID: 2232885
Dhut et al. 1988. Oncogene. 3(5):561-6. PMID: 3078961.
Identification of two normal bcr gene products in the cytoplasm.
Europe PMC ID: 3078961
Walker et al. 1987. Nature. 329(6142):851-3. PMID: 3478595.
Novel chimaeric protein expressed in Philadelphia positive acute lymphoblastic leukaemia.
Europe PMC ID: 3478595
Add a reference
References: 6 entries
Dhut et al. 1990. Leukemia. 4(11):745-50. PMID: 2232885.
BCR-ABL and BCR proteins: biochemical characterization and localization.
Dhut et al. 1988. Oncogene. 3(5):561-6. PMID: 3078961.
Identification of two normal bcr gene products in the cytoplasm.
Walker et al. 1987. Nature. 329(6142):851-3. PMID: 3478595.
Novel chimaeric protein expressed in Philadelphia positive acute lymphoblastic leukaemia.
Add a reference
