Anti-PyLT [PyC]
Invented at Cancer Research UK London Research Institute: Lincoln's Inn Fields
- Datasheet
- References (4)
- Inventor Info
Info
| Catalogue Number | 151188 |
| Applications | IF IP WB |
| Antigen/Gene or Protein Targets | Polyoma virus Early antigens |
| Reactivity | Virus |
| Relevance | The mouse polyoma virus (Py) is an oncogenic virus, which encodes for three early proteins, large, middle and small T (tumour) antigen. PyC allows the detection and isolation of all three viral T antigens. |
| Host | Rat |
| Immunogen | Polyoma virus-transformed Wistar rat fibroblast cell line Py REWA5/T1A1. |
| Subclass | IgG2b |
| Molecular Weight (kDa) | 100/55/23 |
| Myeloma Used | P3/NS1/1-Ag4.1 |
| Recommended Growing Conditions | RPMI 1640 + 5% FCS |
| Notes | Large T antigen: 100kDa, Middle T antigen: 55kDa, Small T antigen 23kDa. These antigens indicate a nuclear and cytoplasmic localisation in cells infected or transformed by polyoma virus. |
| Research Area | Virology |
References: 4 entries
Dilworth et al. 1982. EMBO J. 1(11):1319-28. PMID: 6327264.
Dilworth et al. 1982. Proc Natl Acad Sci U S A. 79(4):1059-63. PMID: 6175960.
Monoclonal antibodies against polyoma virus tumor antigens.
Europe PMC ID: 6175960
Protein kinase activities associated with distinct antigenic forms of polyoma virus middle T-antigen.
Europe PMC ID: 6327264
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References: 4 entries
Dilworth et al. 1982. EMBO J. 1(11):1319-28. PMID: 6327264.
Dilworth et al. 1982. Proc Natl Acad Sci U S A. 79(4):1059-63. PMID: 6175960.
Monoclonal antibodies against polyoma virus tumor antigens.
Protein kinase activities associated with distinct antigenic forms of polyoma virus middle T-antigen.
Add a reference
