Anti-Integrin b1 [4B7]
Invented at Queen Mary University of London
- Datasheet
- References (2)
- Inventor Info
Info
| Catalogue Number | 151222 |
| Applications | FACS IHC IF IP Fn |
| Antigen/Gene or Protein Targets | Integrin ß1 (CD29) |
| Reactivity | Human |
| Relevance | Integrins are heterodimeric cell surface receptors composed of alpha and beta subunits, which mediate cell-cell and cell-extracellular matrix attachments. Aberrant integrin expression has been found in many epithelial tumours. Changes in integrin expression have been shown to be important for the growth and early metastatic capacity of melanoma cells. Loss of integrin beta 1 is associated with the development of some epithelial tumours. |
| Host | Mouse |
| Immunogen | Ocular melanoma cell line V+B2 |
| Subclass | IgG1 |
| Recommended Growing Conditions | DMEM + 5% FCS |
| Strain | Balb/c |
| Notes |
Frozen Sections (2 µg/ml) Immunofluorescence (2.5 µg/ml) Immunoprecipitation (1 µg/sample) Paraffin Sections (2 µg/ml, no pre-treatment required) Immunoblotting (not recommended) |
| Research Area | Adhesion, Developmental Biology, Drug Discovery & Development, Stem Cell Biology |
References: 2 entries
Marshall et al. 1998. Br J Cancer. 77(4):522-9. PMID: 9484806.
Comparative analysis of integrins in vitro and in vivo in uveal and cutaneous melanomas.
Europe PMC ID: 9484806
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References: 2 entries
Marshall et al. 1998. Br J Cancer. 77(4):522-9. PMID: 9484806.
Comparative analysis of integrins in vitro and in vivo in uveal and cutaneous melanomas.
Add a reference
