- Datasheet
- References (4)
- Inventor Info
Info
| Catalogue Number | 151255 |
| Applications | IHC IP WB |
| Antigen/Gene or Protein Targets | Activating Protein 2 (AP-2) gamma |
| Reactivity | Human and Mouse |
| Relevance | AP-2 is a family of developmentally regulated transcription factors which also play a role in breast cancer and melanoma. AP-2ß may be important in cardiac and kidney development. The AP-2 transcription factors form the OB2 complex that has been shown to up-regulate c-erb-B2 transcription. |
| Host | Mouse |
| Immunogen | Bacterially produced AP-2a/AP-2g fusion protein (c-terminal half of AP-2 gamma) |
| Positive Control | MCF7 cells |
| Subclass | IgG1 |
| Molecular Weight (kDa) | 50 |
| Myeloma Used | Sp2/0-Ag14 |
| Recommended Growing Conditions | E4 + 10% FCS |
| Strain | Balb/c |
| Notes | Antigen recovery will improve staining on paraffin sections. |
| Research Area | Cancer, Cardiovascular, Epigenetics & Nuclear Signalling |
References: 4 entries
Gee et al. 2009. J Pathol. 217(1):32-41. PMID: 18825690.
Overexpression of TFAP2C in invasive breast cancer correlates with a poorer response to anti-hormone therapy and reduced patient survival.
Europe PMC ID: 18825690
Eloranta et al. 2002. J Biol Chem. 277(34):30798-804. PMID: 12072434.
Transcription factor AP-2 interacts with the SUMO-conjugating enzyme UBC9 and is sumolated in vivo.
Europe PMC ID: 12072434
Add a reference
References: 4 entries
Gee et al. 2009. J Pathol. 217(1):32-41. PMID: 18825690.
Overexpression of TFAP2C in invasive breast cancer correlates with a poorer response to anti-hormone therapy and reduced patient survival.
Eloranta et al. 2002. J Biol Chem. 277(34):30798-804. PMID: 12072434.
Transcription factor AP-2 interacts with the SUMO-conjugating enzyme UBC9 and is sumolated in vivo.
Add a reference
Inventor Information
Inventors
|
Helen Hurst |
