InvEE Mouse
Invented by Prof Fiona Watt from King's College London
Invented at Cancer Research UK London Research Institute: Lincoln's Inn Fields
- Datasheet
- References (2)
- Inventor Info
Info
| Catalogue Number | 151444 |
| Antigen/Gene or Protein Targets | MEK1 |
| Relevance | A transgenic mouse expressing constitutively active MEK 1 in the epidermis. The mouse displays many phenotypes associated with psoriasis including abnormal keratinocyte differentation, hyperproliferation of keratinocytes and infiltration of inflammatory elements. Disease model for psoriasis; in vivo study of constituitively active murine MEK1 mutant (S217E/S221E) in skin. |
| Production Details | An involucrin - MEK1 transgene expression construct was injected into male pronucleus of fertilized F1 hybrid CBAxC57Bl/6 embryos. Transgene-positive mice were mated with wildtype F1 CBAxC57BL/6 to generate founder lines. |
| Conditional | Yes |
| Conditional Description | Conditional expression of MEK1 under involucrin promoter giving tissue-specific suprabasal epidermal expression. |
| Research Area | Cell Signaling & Signal Transduction, Genetic Studies Tools |
References: 2 entries
Carroll et al. 1995. Cell. 83(6):957-68. PMID: 8521519.
Suprabasal integrin expression in the epidermis of transgenic mice results in developmental defects and a phenotype resembling psoriasis.
Europe PMC ID: 8521519
Add a reference
References: 2 entries
Carroll et al. 1995. Cell. 83(6):957-68. PMID: 8521519.
Suprabasal integrin expression in the epidermis of transgenic mice results in developmental defects and a phenotype resembling psoriasis.
Add a reference
