JIM1 Cell Line
Invented at University Of Birmingham
- Datasheet
- References (8)
- Inventor Info
Info
| Catalogue Number | 151449 |
| Host | Human |
| Tissue | Blood |
| Disease Keywords | Human multiple myeloma, cancer |
| Model | Tumour line |
| Relevance | JIM1 was established from plasma myeloma cells derived from pleural fluid of an advanced multiple myeloma patient, and is homoplastic with the cell line JIM3. It allows in vitro study and comparison of genetic instability in myeloma tumour lines and in vitro study of the effects of DNA repair deficiency in myeloma tumour lines. JIM1 shows typical plasma cell phenotype (CD38, PCA-1 8A and CD24 positive), deficient in DNA repair. |
| Production Details | Derived from plasma myeloma cells from pleural fluid of advanced multiple myeloma female patient. |
| Research Area | Cancer, DNA Damage and Repair, Drug Discovery & Development |
| Growth/Phenotype Keywords | Suspension |
| Recommended Growing Conditions | Dexter culture medium, consisting of Fischer's medium + 20% FCS +10-7 M hydrocortisone sodium succinate. Seed at 2-9 x 10 5 cells/cm3 5% CO2; 37°C |
| Notes | STR profiling showed that this cell line is of female origin |
| Cellosaurus ID | CVCL_2532 |
References: 8 entries
Brito et al. 2009. Haematologica. 94(1):78-86. PMID: 19059936.
MMSET deregulation affects cell cycle progression and adhesion regulons in t(4;14) myeloma plasma cells.
Europe PMC ID: 19059936
Leone et al. 2008. Clin Cancer Res. 14(19):6033-41. PMID: 18829482.
Deletions of CDKN2C in multiple myeloma: biological and clinical implications.
Europe PMC ID: 18829482
Velangi et al. 2004. Carcinogenesis. 25(10):1795-803. PMID: 15142887.
DNA mismatch repair pathway defects in the pathogenesis and evolution of myeloma.
Europe PMC ID: 15142887
Hamilton et al. 1991. Leukemia. 5(9):768-71. PMID: 1943229.
Normal and neoplastic human plasma cells express bcl-2 antigen.
Europe PMC ID: 1943229
Add a reference
References: 8 entries
Brito et al. 2009. Haematologica. 94(1):78-86. PMID: 19059936.
MMSET deregulation affects cell cycle progression and adhesion regulons in t(4;14) myeloma plasma cells.
Leone et al. 2008. Clin Cancer Res. 14(19):6033-41. PMID: 18829482.
Deletions of CDKN2C in multiple myeloma: biological and clinical implications.
Velangi et al. 2004. Carcinogenesis. 25(10):1795-803. PMID: 15142887.
DNA mismatch repair pathway defects in the pathogenesis and evolution of myeloma.
Hamilton et al. 1991. Leukemia. 5(9):768-71. PMID: 1943229.
Normal and neoplastic human plasma cells express bcl-2 antigen.
Add a reference
