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Catalogue Number
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151550 |
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Antigen/Gene or Protein Targets
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Alpha6Beta4 Integrin
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Disease Keywords
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Cancer; squamous cell carcinoma;
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Relevance
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Chemically-induced skin tumourigenesis model; in vivo study of alpha6 and beta4 integrin transgene expression in skin. Ninety six percent of alpha6beta4 transgenic mice develop squamous cell carcinoma, compared to 44% wildtype. Of those mice developing tumours, 68% alpha6beta4 develop metastasis, compared to 8% wildtype. TGF-beta signalling is disrupted in alpha6beta4 transgenic mice.
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Production Details
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Involucrin - integrin transgene expression constructs were injected into fertilized oocytes from F1 hybrid CBAxC57Bl/6 mice. Transgene-positive mice were back-crossed to generate individual founder lines. alpha6 founder line was crossed with beta4 founder line to generate alpha6beta4 line.
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Conditional
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Yes
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Conditional Description
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Conditional expression of integrins under involucrin promoter giving tissue-specific suprabasal epidermal expression.
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Growth/Phenotype Keywords
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Tumourigenesis (skin);
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Mouse Genetic Background/Cross History
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CBA x C57BL/6
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Zygosity
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Heterozygous
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Research Area
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Cancer, Cell Type or Organelle Marker, Cell Signaling & Signal Transduction, Genetic Studies Tools, Stem Cell Biology
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