Inva2b1 Mouse
Invented by Prof Fiona Watt from King's College London
Invented at Cancer Research UK London Research Institute: Lincoln's Inn Fields
- Datasheet
- References (2)
- Inventor Info
Info
| Catalogue Number | 151551 |
| Antigen/Gene or Protein Targets | Alpha2 intergrin, beta1 integrin |
| Disease Keywords | Psoriasis |
| Relevance | Disease model for psoriasis; in vivo study of human alpha2 and beta1 integrin transgene expression in skin. |
| Production Details | Involucrin - integrin transgene expression constructs were injected into fertilized oocytes from F1 hybrid CBAxC57Bl/6 mice. Transgene-positive mice were back-crossed to generate individual founder lines. alpha2 founder line was crossed with beta1 founder line to generate alpha2beta1 line. |
| Conditional | Yes |
| Conditional Description | Conditional expression of integrins under involucrin promoter giving tissue-specific suprabasal epidermal expression. |
| Growth/Phenotype Keywords | Skin abnormalities (abnormal keratinocyte differentiation, hyperproliferation, inflammatory lesions) |
| Mouse Genetic Background/Cross History | CBA/C57BL/6 |
| Zygosity | Heterozygous |
| Research Area | Cell Type or Organelle Marker, Genetic Studies Tools |
| Notes | Mice present phenotype very similar to human psoriasis disease. |
References: 2 entries
Carroll et al. 1995. Cell. 83(6):957-68. PMID: 8521519.
Suprabasal integrin expression in the epidermis of transgenic mice results in developmental defects and a phenotype resembling psoriasis.
Europe PMC ID: 8521519
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References: 2 entries
Carroll et al. 1995. Cell. 83(6):957-68. PMID: 8521519.
Suprabasal integrin expression in the epidermis of transgenic mice results in developmental defects and a phenotype resembling psoriasis.
Add a reference
