UNG Mouse
Invented at Cancer Research UK London Research Institute: Clare Hall Laboratories
- Datasheet
- References (4)
- Inventor Info
Info
| Catalogue Number | 151556 |
| Antigen/Gene or Protein Targets | Uracil-DNA Glycosylase (UNG) |
| Disease Keywords | Cancer, B cell lymphoma |
| Relevance | In vivo study of UNG knockout and DNA mismatch mutation during DNA synthesis. Mice develop B cell lymphoma and are abnormally defective in their immune response. There are also mouse embryonic fibroblasts from this line available. |
| Production Details | A ung targeting vector, replacing exon 4 with a resistance cassette, was transfected into 129 ES cells. Properly targeted ES cells containing a homologous recombination event were selected, cloned, and injected into C57BL6 blastocysts. Chimeric mice were mated with C57BL6 mice to generate heterozygotes. Heterozygous mice were crossed to generate homozygous Ung-/- mice. |
| Conditional | No |
| Mouse Genetic Background/Cross History | 129/C57BL/6 |
| Zygosity | Homozygous |
| Research Area | Cancer, DNA Damage and Repair, Genetic Studies Tools, Immunology |
References: 4 entries
Nilsen et al. 2003. Oncogene. 22(35):5381-6. PMID: 12934097.
Gene-targeted mice lacking the Ung uracil-DNA glycosylase develop B-cell lymphomas.
Europe PMC ID: 12934097
Nilsen et al. 2000. Mol Cell. 5(6):1059-65. PMID: 10912000.
Uracil-DNA glycosylase (UNG)-deficient mice reveal a primary role of the enzyme during DNA replication.
Europe PMC ID: 10912000
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References: 4 entries
Nilsen et al. 2003. Oncogene. 22(35):5381-6. PMID: 12934097.
Gene-targeted mice lacking the Ung uracil-DNA glycosylase develop B-cell lymphomas.
Nilsen et al. 2000. Mol Cell. 5(6):1059-65. PMID: 10912000.
Uracil-DNA glycosylase (UNG)-deficient mice reveal a primary role of the enzyme during DNA replication.
Add a reference
