K5R2b Null Mouse
Invented at Cancer Research UK London Research Institute: Lincoln's Inn Fields
- Datasheet
- References (0)
- Inventor Info
Info
| Catalogue Number | 151561 |
| Antigen/Gene or Protein Targets | Fibroblast growth factor receptor 2 isoform IIIb (FGFR2IIIb) |
| Disease Keywords | Gastric cancer |
| Relevance | A mouse model with epidermal FgfR 2b expression knocked out. The mouse lives a normal life span but has altered hair morphology. It has a tendency to develop skin papillomas spontaneously and development of these can be accelerated greatly by use of a carcinogen. |
| Production Details | Homozygous Fgfr2bflox/flox mice, carrying a loxP flanked IIIb exon of FGFR2, were crossed with male heterozygous K5-Cre mice, carrying Cre recombinase transgene under control of the Keratin-5 promoter. Mice were maintained on a mixed 129/C57BL6 background. |
| Conditional | Yes |
| Conditional Description | Fgfr2bflox/flox mouse crossed with K5-Cre mouse (tissue-specific Cre expression in skin) giving tissue-specific knockout of FGFR2 IIIb isoform in skin. |
| Growth/Phenotype Keywords | Skin abnormalities, Tumourigenesis |
| Research Area | Cancer, Cell Signaling & Signal Transduction, Genetic Studies Tools, Immunology |
| Notes |
The K5-R2b-null mouse is an ideal tool in the study of the tumour suppressive role of the FGFR2 IIIb isoform in skin tumourigenesis. Skin tumours develop in K5-R2b-null mice following two-step carcinogen treatment with DMBA and TPA. |
References
There are 0 reference entries for this reagent.
References: 0 entry
There is no reference for this reagent yet, feel free to use the button below to suggest one.
Add a reference
References: 0 entry
There is no reference for this reagent yet, feel free to use the button below to suggest one.
Add a reference
