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Mouse Models

K14MycER Mouse

Invented by Prof Fiona Watt from King's College London
Invented at Cancer Research UK London Research Institute: Lincoln's Inn Fields
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Catalogue Number 151563
Antigen/Gene or Protein Targets cMyc protooncogene (Myc) fused with estragen receptor (ER).
Disease Keywords Cancer; telogen effluvium (hair loss)
Relevance In vivo study of Myc activation in skin; in vivo study of skin cell proliferation & differentiation (sebocytes, epidermis)
Production Details A MycER transgenic vector, containing a c-Myc-2 cDNA fused to the hormone-binding domain of a mutant mouse estragen receptor under the control of the keratin 14 promoter, was injected into fertilised CBA/C57BL6 ooctyes. Founders were backcrossed to establish transgenic lines.
Conditional Yes
Conditional Description Conditional expression of MycER under Keratin 14 promoter giving tissue-specific epidermal expression
Growth/Phenotype Keywords Skin abnormalities (hyperproliferation; hair follicle; sebaceous gland);
Research Area Cancer, Epigenetics & Nuclear Signalling, Genetic Studies Tools, Stem Cell Biology

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