K14dNb Mouse
Invented by Prof Fiona Watt from King's College London
Invented at Cancer Research UK London Research Institute: Lincoln's Inn Fields
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Info
| Catalogue Number | 151565 |
| Antigen/Gene or Protein Targets | Beta-catenin N-terminal truncation (deltaNbeta-catenin) fused with estrogen receptor (ER) |
| Disease Keywords | Cancer; colorectal cancer; melanoma; telogen effluvium (hair loss); |
| Relevance | In vivo study of beta-catenin activation in skin; model for hair growth & follicle formation; |
| Production Details | A deltaNbeta-cateninER transgenic vector, containing an N-terminally truncated beta-catenin cDNA fused to the hormone-binding domain of a mutant mouse estragen receptor under the control of the keratin 14 promoter, was injected into fertilised CBA/C57BL6 ooctyes. Founders were backcrossed to establish transgenic lines. |
| Conditional | Yes |
| Conditional Description | Conditional expression of deltaNbeta-cateninER under Keratin 14 promoter giving tissue-specific epidermal expression. |
| Growth/Phenotype Keywords | Skin abnormalities (hair follicle); |
| Research Area | Cancer, Cardiovascular, Cell Signaling & Signal Transduction, Genetic Studies Tools, Neurobiology, Stem Cell Biology |
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