Anti-TFF1 [PS2GE2]
Invented at Cancer Research UK London Research Institute: Lincoln's Inn Fields
- Datasheet
- References (1)
- Inventor Info
Info
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| Catalogue Number | 151569 |
| Applications | FACS IHC IF IP WB |
| Antigen/Gene or Protein Targets | Trefoil factor 1 (TFF1), also known as pS2 |
| Synonyms |
BCEI, Breast Cancer Estrogen Inducible Protein, Gastrointestinal Trefoil Protein, Gastrointestinal trefoil protein pS2, HP1A, HPS2, pNR2, TFF1, Trefoil Factor 1 Human Entrez Gene ID 7031 Human SwissProt P04155 Human Unigene 162807 Human Gene Symbol TFF1 Human Chromosome Location 16p11.2 |
| Reactivity | Human |
| Relevance | pS2 is a cysteine-rich, 6.5kDa protein found in both oestrogen-dependent (breast tumours) and oestrogen-independent tissues (normal stomach mucosa). About 60% of breast carcinomas are positive for pS2. Staining is cytoplasmic, often with localisation to the Golgi apparatus. pS2 is primarily expressed in oestrogen receptor-positive breast tumours. |
| Host | Mouse |
| Immunogen | A synthetic peptide of 28 amino acid residues from the C-terminus of human pS2 protein |
| Positive Control | Normal stomach, breast or ovarian carcinoma |
| Subclass | IgG1 kappa |
| Molecular Weight (kDa) | 6.5 |
| Notes |
Cellular Localization: Cytoplasmic Flow Cytometry (0.5-1ug/million cells); Immunofluorescence (0.5-1ug/ml); Immunohistology (Formalin-fixed) (0.5-1.0ug/ml for 30 minutes at RT) (Staining of formalin-fixed tissues requires boiling tissue sections in 10mM Citrate Buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes) |
| Research Area | Cancer, Cell Type or Organelle Marker, Epigenetics & Nuclear Signalling |
