Anti-BRCA2, Polyclonal [MTA42]
Invented at Cancer Research UK London Research Institute: Clare Hall Laboratories
- Datasheet
- References (4)
- Inventor Info
Info
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| Catalogue Number | 151571 |
| Applications | ChIP IP WB |
| Antigen/Gene or Protein Targets | BRCA2 |
| Synonyms | BRCA 2, BRCA1/BRCA2 containing complex subunit 2, Brca2, BRCA2_HUMAN, BRCC 2, BRCC2, Breast and ovarian cancer susceptibility gene early onset, Breast cancer 2 early onset, Breast Cancer 2 tumor suppressor, Breast cancer susceptibility protein BRCA2, Breast cancer type 2 susceptibility protein, BROVCA2, FACD, FAD 1, FAD, FAD1, FANCB, FANCD 1 |
| Reactivity | Human and Mouse |
| Relevance | Breast Cancer Type 2 susceptibility protein (BRCA2) is a tumour suppressor gene. BRCA2 is involved in the repair of chromosomal damage, specifically in localising Rad51 to double strand breaks. BRCA2 and BRCA1 are frequently mutated in cases of hereditary breast and ovarian cancer. |
| Host | Rabbit |
| Immunogen | Human BRCA2 sequence |
| Concentration | 1.47 mg/ml |
| Formulation | PBS, 0.1% NaN3 |
| Molecular Weight (kDa) | 370 |
| Notes | Suggested dilutions for WB: 1/500 to 1/1000 |
| Positive Control | HeLa and U2OS human cells |
| Research Area | Cancer, DNA Damage and Repair, Epigenetics & Nuclear Signalling |
References: 4 entries
Zhang et al. 2012. Clin Cancer Res. 18(21):5961-71. PMID: 22977194.
WB
FoxM1 inhibition sensitizes resistant glioblastoma cells to temozolomide by downregulating the expression of DNA-repair gene Rad51.
Europe PMC ID: 22977194
Badie et al. 2010. Nat Struct Mol Biol. 17(12):1461-9. PMID: 21076401.
ChIP WB
BRCA2 acts as a RAD51 loader to facilitate telomere replication and capping.
Europe PMC ID: 21076401
Add a reference
References: 4 entries
Zhang et al. 2012. Clin Cancer Res. 18(21):5961-71. PMID: 22977194.
WB
FoxM1 inhibition sensitizes resistant glioblastoma cells to temozolomide by downregulating the expression of DNA-repair gene Rad51.
Badie et al. 2010. Nat Struct Mol Biol. 17(12):1461-9. PMID: 21076401.
ChIP WB
BRCA2 acts as a RAD51 loader to facilitate telomere replication and capping.
Add a reference
