Anti-MMP1 [3B6]
Invented by Ayham Alnabulsi from Vertebrate Antibodies Limited
Invented at Vertebrate Antibodies Limited
- Datasheet
- References (12)
- Inventor Info
Info
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| Catalogue Number | 151618 |
| Applications | IHC IF IP WB |
| Antigen/Gene or Protein Targets | Human matrix metalloproteinase 1 (MMP-1) |
| Reactivity | Human |
| Relevance | MMP1 cleaves collagens of types I, II, and III at one site in the helical domain. MMP1 also cleaves collagens of types VII and X. In case of HIV infection, interacts and cleaves the secreted viral Tat protein, leading to a decrease in neuronal Tat's mediated neurotoxicity. |
| Host | Mouse |
| Immunogen | Ovalbumin-conjugated synthetic peptide; CSSFGFPRTVKH |
| Positive Control | IHC: formalin-fixed, paraffin-embedded colonic adenocarcinomaWestern blot: rhMMP-1, 400 ng per lane |
| Subclass | IgG1 |
| Myeloma Used | P3X63Ag8.653 |
| Strain | Balb/c |
| Notes | (i) no cross-reactivity in immunoblot panel (MMP-2, -3, -9); (ii) staining in antigen-positive wax-imbedded tissues |
| Research Area | Adhesion, Cancer, Cardiovascular, Epigenetics & Nuclear Signalling |
References: 12 entries
Jeffery et al. 2009. Histopathology. 54(7):820-8. PMID: 19635101.
The matrix metalloproteinase/tissue inhibitor of matrix metalloproteinase profile in colorectal polyp cancers.
Europe PMC ID: 19635101
Lyall et al. 2006. Clin Cancer Res. 12(4):1184-91. PMID: 16489072.
Profiling markers of prognosis in colorectal cancer.
Europe PMC ID: 16489072
Curran et al. 2004. Clin Cancer Res. 10(24):8229-34. PMID: 15623598.
Matrix metalloproteinase/tissue inhibitors of matrix metalloproteinase phenotype identifies poor prognosis colorectal cancers.
Europe PMC ID: 15623598
Murray et al. 1998. Gut. 43(6):791-7. PMID: 9824606.
Matrix metalloproteinases and their inhibitors in gastric cancer.
Europe PMC ID: 9824606
Murray et al. 1998. J Pathol. 185(3):256-61. PMID: 9771478.
Matrix metalloproteinase-1 is associated with poor prognosis in oesophageal cancer.
Europe PMC ID: 9771478
Murray et al. 1996. Nat Med. 2(4):461-2. PMID: 8597958.
Matrix metalloproteinase-1 is associated with poor prognosis in colorectal cancer.
Europe PMC ID: 8597958
Add a reference
References: 12 entries
Jeffery et al. 2009. Histopathology. 54(7):820-8. PMID: 19635101.
The matrix metalloproteinase/tissue inhibitor of matrix metalloproteinase profile in colorectal polyp cancers.
Lyall et al. 2006. Clin Cancer Res. 12(4):1184-91. PMID: 16489072.
Profiling markers of prognosis in colorectal cancer.
Curran et al. 2004. Clin Cancer Res. 10(24):8229-34. PMID: 15623598.
Matrix metalloproteinase/tissue inhibitors of matrix metalloproteinase phenotype identifies poor prognosis colorectal cancers.
Murray et al. 1998. Gut. 43(6):791-7. PMID: 9824606.
Matrix metalloproteinases and their inhibitors in gastric cancer.
Murray et al. 1998. J Pathol. 185(3):256-61. PMID: 9771478.
Matrix metalloproteinase-1 is associated with poor prognosis in oesophageal cancer.
Murray et al. 1996. Nat Med. 2(4):461-2. PMID: 8597958.
Matrix metalloproteinase-1 is associated with poor prognosis in colorectal cancer.
Add a reference
