Anti-MMP3 [1B4]
Invented by Ayham Alnabulsi from Vertebrate Antibodies Limited
Invented at Vertebrate Antibodies Limited
- Datasheet
- References (10)
- Inventor Info
Info
![Image for Anti-MMP3 [1B4]](https://res.cloudinary.com/ximbio/image/upload/c_fit,fl_lossy,q_auto/02ef9436-f62c-4827-ae5b-41e7b03d7471.jpg)
![Image for Anti-MMP3 [1B4]](https://res.cloudinary.com/ximbio/image/upload/c_fit,fl_lossy,q_auto/ad1406cd-af03-41bb-a350-0456f5242b64.jpg)
![Image for Anti-MMP3 [1B4]](https://res.cloudinary.com/ximbio/image/upload/c_fit,fl_lossy,q_auto/aa803aa6-6baf-43cd-9752-bd436d66cec5.jpg)
![Image for Anti-MMP3 [1B4]](https://res.cloudinary.com/ximbio/image/upload/c_limit,fl_lossy,h_282,q_auto,w_368/02ef9436-f62c-4827-ae5b-41e7b03d7471.jpg)
![Image for Anti-MMP3 [1B4]](https://res.cloudinary.com/ximbio/image/upload/c_limit,fl_lossy,h_282,q_auto,w_368/ad1406cd-af03-41bb-a350-0456f5242b64.jpg)
![Image for Anti-MMP3 [1B4]](https://res.cloudinary.com/ximbio/image/upload/c_limit,fl_lossy,h_282,q_auto,w_368/aa803aa6-6baf-43cd-9752-bd436d66cec5.jpg)
![Image thumbnail for Anti-MMP3 [1B4]](https://res.cloudinary.com/ximbio/image/upload/c_fit,fl_lossy,h_45,q_auto/02ef9436-f62c-4827-ae5b-41e7b03d7471.jpg)
![Image thumbnail for Anti-MMP3 [1B4]](https://res.cloudinary.com/ximbio/image/upload/c_fit,fl_lossy,h_45,q_auto/ad1406cd-af03-41bb-a350-0456f5242b64.jpg)
![Image thumbnail for Anti-MMP3 [1B4]](https://res.cloudinary.com/ximbio/image/upload/c_fit,fl_lossy,h_45,q_auto/aa803aa6-6baf-43cd-9752-bd436d66cec5.jpg)
| Catalogue Number | 151620 |
| Applications | ELISA IHC IF IP WB |
| Antigen/Gene or Protein Targets | Human matrix metalloproteinase 3 (MMP-3) |
| Reactivity | Human |
| Relevance | Human matrix metalloproteinase 3 (MMP-3) is a member of the matrix metalloproteinases (MMP) family that are peptidases involved in the breakdown of extracellular matrix proteins. MMP-3 degrades fibronectin, laminin, gelatins of type I, III, IV, and V; collagen of type II, III, IV, X, and IX, and proteoglycans. In addition, MMP-3 can also activate other MMPs such as MMP-1, MMP-7, and MMP-9, rendering MMP-3 crucial in connective tissue remodeling. The enzyme is also thought to be involved in wound repair, progression of atherosclerosis, and tumor initiation. |
| Host | Mouse |
| Immunogen | Ovalbumin-conjugated synthetic peptide; CKSLRKLEPELH |
| Positive Control | IHC: formalin-fixed, paraffin-embedded lung containing intra-alveolar macrophageswestern blot: rhMMP-3, 400 ng per lane |
| Subclass | IgG1 |
| Myeloma Used | P3X63Ag8.653 |
| Strain | Balb/c |
| Notes | Western blot: not reactive with MMP-1, MMP-2, MMP-9 |
| Research Area | Adhesion, Cancer, Cardiovascular, Epigenetics & Nuclear Signalling |
References: 10 entries
Jeffery et al. 2009. Histopathology. 54(7):820-8. PMID: 19635101.
The matrix metalloproteinase/tissue inhibitor of matrix metalloproteinase profile in colorectal polyp cancers.
Europe PMC ID: 19635101
Lyall et al. 2006. Clin Cancer Res. 12(4):1184-91. PMID: 16489072.
Profiling markers of prognosis in colorectal cancer.
Europe PMC ID: 16489072
Curran et al. 2004. Clin Cancer Res. 10(24):8229-34. PMID: 15623598.
Matrix metalloproteinase/tissue inhibitors of matrix metalloproteinase phenotype identifies poor prognosis colorectal cancers.
Europe PMC ID: 15623598
Murray et al. 1998. Gut. 43(6):791-7. PMID: 9824606.
Matrix metalloproteinases and their inhibitors in gastric cancer.
Europe PMC ID: 9824606
Murray et al. 1998. J Pathol. 185(3):256-61. PMID: 9771478.
Matrix metalloproteinase-1 is associated with poor prognosis in oesophageal cancer.
Europe PMC ID: 9771478
Add a reference
References: 10 entries
Jeffery et al. 2009. Histopathology. 54(7):820-8. PMID: 19635101.
The matrix metalloproteinase/tissue inhibitor of matrix metalloproteinase profile in colorectal polyp cancers.
Lyall et al. 2006. Clin Cancer Res. 12(4):1184-91. PMID: 16489072.
Profiling markers of prognosis in colorectal cancer.
Curran et al. 2004. Clin Cancer Res. 10(24):8229-34. PMID: 15623598.
Matrix metalloproteinase/tissue inhibitors of matrix metalloproteinase phenotype identifies poor prognosis colorectal cancers.
Murray et al. 1998. Gut. 43(6):791-7. PMID: 9824606.
Matrix metalloproteinases and their inhibitors in gastric cancer.
Murray et al. 1998. J Pathol. 185(3):256-61. PMID: 9771478.
Matrix metalloproteinase-1 is associated with poor prognosis in oesophageal cancer.
Add a reference
