ATF2 Deleter Mouse
Invented at Cancer Research UK Manchester Institute
- Datasheet
- References (2)
- Inventor Info
Info
| Catalogue Number | 151646 |
| Antigen/Gene or Protein Targets | ATF2 |
| Relevance | Deletion of ATF2 DNA binding domain. Transcription factor (BZIP-type, AP1-family). |
| Production Details | Atf2 genomic sequences were isolated by screening a 129/ola mouse cosmid library (RZPD), cloned into pPGKneobpAlox2PGKD, transfected into 129/ola embryonic stem cells. Transgenic animals were produced by blastocyst injection and offspring mice were backcrossed at least six times with C57 Bl/6 mice to produce isogenic lines. |
| Conditional | No |
| Growth/Phenotype Keywords | Homozygous postnatal lethality, heterozygous normal phenotype |
| Mouse Genetic Background/Cross History | C57/Bl6 |
| Zygosity | Heterozygous |
| Research Area | Cell Cycle, Cell Signaling & Signal Transduction, Developmental Biology, Epigenetics & Nuclear Signalling, Genetic Studies Tools, Immunology |
References: 2 entries
Breitwieser et al. 2007. Genes Dev. 21(16):2069-82. PMID: 17699753.
Feedback regulation of p38 activity via ATF2 is essential for survival of embryonic liver cells.
Europe PMC ID: 17699753
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References: 2 entries
Breitwieser et al. 2007. Genes Dev. 21(16):2069-82. PMID: 17699753.
Feedback regulation of p38 activity via ATF2 is essential for survival of embryonic liver cells.
Add a reference
