Anti-CD70 [TAN 1-7]
Invented at University of Southampton
- Datasheet
- References (6)
- Inventor Info
Info
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| Catalogue Number | 151721 |
| Applications | ELISA FACS IF Fn |
| Antigen/Gene or Protein Targets | CD70 |
| Synonyms | CD70 Molecule; Tumor Necrosis Factor Ligand Superfamily Member 7; CD27 Ligand; CD27LG; TNFSF7; CD27L; Tumor Necrosis Factor Ligand 8A; Surface Antigen CD70; Ki-24 Antigen; CD70 Antigen; TNLG8A |
| Reactivity | Mouse |
| Relevance |
Monoclonal antibody directed against CD70 cytokine, capable of blocking the CD70-CD27 interaction involved in B and T cell activation. Background and Research Application CD70 is a cytokine that belongs to the tumour necrosis factor (TNF) ligand family. This cytokine is a ligand for TNFRSF27/CD27. It is a surface antigen on activated, but not on resting, T and B lymphocytes and dendritic cells. It induces proliferation of co-stimulated T cells, enhances the generation of cytolytic T cells, and contributes to T cell activation. This cytokine is also reported to play a role in regulating B cell activation, cytotoxic function of natural killer cells, and immunoglobulin synthesis. CD70 expression is induced upon activation of DCs, indicating that the CD70-CD27 interaction could take place during the activation of naive T cells by DCs. Anti-CD70 is non-depleting and blocks the CD70-CD27 interaction. CD70 expression is thought to play a role in autoimmune disease regulation, and treatment of autoimmune diseases such as rheumatoid arthritis. |
| Host | Rat |
| Immunogen | Recombinant mouse CD70 (extracellular domain, aa residues 41-195) |
| Immunogen UniProt ID | O55237 |
| Positive Control | Activated dendritic cells |
| Subclass | IgG2a |
| Myeloma Used | NS0 |
| Recommended Growing Conditions | RPMI + 10%FCS+ Penicillin-Streptomycin |
| Notes |
Production Details Purified using multi-step affinity chromatography with protein A. Storage Conditions Store at -20 degrees frozen. Avoid repeated freeze/thaw cycles. Points of Interest This antibody is a non-depleting mAb that blocks the CD70-CD27 interaction. Suggested Dilutions: 1-10mg/ml Concentration 1mg/ml as standard |
| Research Area | Apoptosis and Programmed Cell Death, Cancer, Immunology, Stem Cell Biology |
References: 6 entries
Arora et al. 2014. Immunity. 40(1):105-16. PMID: 24412610.
Fn
A single subset of dendritic cells controls the cytokine bias of natural killer T cell responses to diverse glycolipid antigens.
Europe PMC ID: 24412610
Invariant NKT cells promote CD8+ cytotoxic T cell responses by inducing CD70 expression on dendritic cells.
Europe PMC ID: 18354184
Taraban et al. 2008. J Immunol. 180(7):4615-20. PMID: 18354184.
Rowley et al. 2004. J Immunol. 172(10):6039-46. PMID: 15128787.
Stimulation by soluble CD70 promotes strong primary and secondary CD8+ cytotoxic T cell responses in vivo.
Europe PMC ID: 15128787
Add a reference
References: 6 entries
Arora et al. 2014. Immunity. 40(1):105-16. PMID: 24412610.
Fn
A single subset of dendritic cells controls the cytokine bias of natural killer T cell responses to diverse glycolipid antigens.
Invariant NKT cells promote CD8+ cytotoxic T cell responses by inducing CD70 expression on dendritic cells.
Taraban et al. 2008. J Immunol. 180(7):4615-20. PMID: 18354184.
Rowley et al. 2004. J Immunol. 172(10):6039-46. PMID: 15128787.
Stimulation by soluble CD70 promotes strong primary and secondary CD8+ cytotoxic T cell responses in vivo.
Add a reference
