Anti-Cytochrome P450 2A6, Polyclonal [CYP2A6]
Invented by Prof Roland Wolf from University of Dundee
Invented at University of Dundee
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Info
| Catalogue Number | 151723 |
| Applications | WB |
| Antigen/Gene or Protein Targets | Cytochrome P450 2A6, CYP2A6 |
| Reactivity | Human |
| Relevance | CYP2A6, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by phenobarbital. The enzyme is known to hydroxylate coumarin, and also metabolizes nicotine, aflatoxin B1, nitrosamines, and some pharmaceuticals. This gene is part of a large cluster of cytochrome P450 genes from the CYP2A, CYP2B and CYP2F subfamilies on chromosome 19q. CYP 2A6 exhibits high coumarin 7-hydroxylase activity and can act in the hydroxylation of the anti-cancer drugs cyclophosphamide and ifosphamide. |
| Host | Sheep |
| Immunogen | Purified recombinant human P450s |
| Positive Control | Human Liver Microsomes |
| Research Area | Cancer, Cardiovascular, Cell Signaling & Signal Transduction, Epigenetics & Nuclear Signalling, Metabolism |
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Inventor Information
Inventors
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Prof Roland Wolf |
