Anti-Cytochrome P450 2E1, Polyclonal [CYP2E1]

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Catalogue Number	151725
Applications	WB
Antigen/Gene or Protein Targets	Cytochrome P450 2E1, CYP2E1
Reactivity	Human
Relevance	This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and is induced by ethanol, the diabetic state, and starvation. The enzyme metabolizes both endogenous substrates, such as ethanol, acetone, and acetal, as well as exogenous substrates including benzene, carbon tetrachloride, ethylene glycol, and nitrosamines which are premutagens found in cigarette smoke. Due to its many substrates, this enzyme may be involved in such varied processes as gluconeogenesis, hepatic cirrhosis, diabetes, and cancer.
Host	Sheep
Immunogen	Purified recombinant human P450s
Positive Control	Human Liver Microsomes
Research Area	Cancer, Cardiovascular, Cell Signaling & Signal Transduction, Epigenetics & Nuclear Signalling, Metabolism

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Prof Roland Wolf

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	University of Dundee
	62 reagents listed on Ximbio

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