HBRN Mouse
Invented by Dr Colin Henderson from University of Dundee , Prof Roland Wolf from University of Dundee
Invented at University of Dundee
- Datasheet
- References (4)
- Inventor Info
Info
| Catalogue Number | 151773 |
| Antigen/Gene or Protein Targets | P450, Cyb5 |
| Relevance | Improved model of abrogation of hepatic P450 function. The dual deletion of both Cyb5 and POR almost completely abrogates all hepatic cytochrome P450 activities; the new HBRN model thus provides a more authentic hepatic-P450 null phenotype |
| Production Details | HBRN (Cytb5lox/lox::PORlox/lox ± CreALB) and wild-type (WT; PORlox/lox::Cyb5lox/lox) were generated by crossing HRN (PORlox/lox + CreALB ) and floxed cytochrome b5 mice (Cytb5lox/lox), and thereafter maintained by crossing of homozygous pairs within each line. |
| Conditional | No |
| Mouse Genetic Background/Cross History | C57BL/6J |
| Zygosity | HBRN (Cytb5lox/lox::PORlox/lox ± CreALB) |
| Research Area | Cell Signaling & Signal Transduction, DNA Damage and Repair, Genetic Studies Tools, Metabolism |
References: 4 entries
Henderson et al. 2013. Mol Pharmacol. 83(6):1209-17. PMID: 23530090.
Evidence that cytochrome b5 and cytochrome b5 reductase can act as sole electron donors to the hepatic cytochrome P450 system.
Europe PMC ID: 23530090
Henderson et al. 2003. J Biol Chem. 278(15):13480-6. PMID: 12566435.
Inactivation of the hepatic cytochrome P450 system by conditional deletion of hepatic cytochrome P450 reductase.
Europe PMC ID: 12566435
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References: 4 entries
Henderson et al. 2013. Mol Pharmacol. 83(6):1209-17. PMID: 23530090.
Evidence that cytochrome b5 and cytochrome b5 reductase can act as sole electron donors to the hepatic cytochrome P450 system.
Henderson et al. 2003. J Biol Chem. 278(15):13480-6. PMID: 12566435.
Inactivation of the hepatic cytochrome P450 system by conditional deletion of hepatic cytochrome P450 reductase.
Add a reference
Inventor Information
Inventors
|
Prof Roland Wolf |
