Anti-Fbxo7, Polyclonal [HLA3]
Invented by Dr Heike Laman from University of Cambridge
Invented at University College London
- Datasheet
- References (6)
- Inventor Info
Info
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![Image for Anti-Fbxo7, Polyclonal [HLA3]](https://res.cloudinary.com/ximbio/image/upload/c_limit,fl_lossy,h_282,q_auto,w_368/57137d8a-3485-4e59-a5e4-03749c4e0f61.jpg)
![Image thumbnail for Anti-Fbxo7, Polyclonal [HLA3]](https://res.cloudinary.com/ximbio/image/upload/c_fit,fl_lossy,h_45,q_auto/100fd3bc-1d64-43e4-ac4a-d60f8f71faaa.jpg)
![Image thumbnail for Anti-Fbxo7, Polyclonal [HLA3]](https://res.cloudinary.com/ximbio/image/upload/c_fit,fl_lossy,h_45,q_auto/57137d8a-3485-4e59-a5e4-03749c4e0f61.jpg)
| Catalogue Number | 151883 |
| Applications | IHC IP WB |
| Antigen/Gene or Protein Targets | Fbxo7 |
| Reactivity | Human and Mouse |
| Relevance |
Recessive mutations in FBXO7/PARK15 cause an atypical EOPD. In certain cancers, the protein is highly expressed. These cell lines all express Fbxo7: U2OS, SHSY5Y, HEK293, Jurkat, SKOV3, HeLa, Ba-F3, Nalm6, C33A, MEL, HSPCs, MEFs. |
| Host | Rabbit |
| Immunogen | aa 499-522 of human Fbxo7 synthetic peptide coupled to KLH |
| Molecular Weight (kDa) | ~59/~70 |
| Notes |
Staining Pattern: Nuclear and cytoplasmic, depending on stage of the cell cycle. May be aberrantly localised in pathological conditions. This antibody is not available for licence, please refer to supplier information to find a source of the antibody. |
| Positive Control | Any cultured cell line grown in FBS |
| Research Area | Cell Cycle, Epigenetics & Nuclear Signalling |
References: 6 entries
Burchell et al. 2013. Nat Neurosci. 16(9):1257-65. PMID: 23933751.
The Parkinson's disease-linked proteins Fbxo7 and Parkin interact to mediate mitophagy.
Europe PMC ID: 23933751
Meziane el et al. 2011. J Cell Sci. 124(Pt 13):2175-86. PMID: 21652635.
Knockdown of Fbxo7 reveals its regulatory role in proliferation and differentiation of haematopoietic precursor cells.
Europe PMC ID: 21652635
Laman et al. 2005. EMBO J. 24(17):3104-16. PMID: 16096642.
Transforming activity of Fbxo7 is mediated specifically through regulation of cyclin D/cdk6.
Europe PMC ID: 16096642
Add a reference
References: 6 entries
Burchell et al. 2013. Nat Neurosci. 16(9):1257-65. PMID: 23933751.
The Parkinson's disease-linked proteins Fbxo7 and Parkin interact to mediate mitophagy.
Meziane el et al. 2011. J Cell Sci. 124(Pt 13):2175-86. PMID: 21652635.
Knockdown of Fbxo7 reveals its regulatory role in proliferation and differentiation of haematopoietic precursor cells.
Laman et al. 2005. EMBO J. 24(17):3104-16. PMID: 16096642.
Transforming activity of Fbxo7 is mediated specifically through regulation of cyclin D/cdk6.
Add a reference
