Fluorescent Probe FITC-Trehalose Small Molecule (Tool Compound)
Invented at University of Oxford
- Datasheet
- References (2)
- Inventor Info
Info
| Antigen/Gene or Protein Targets | Extracellular Ag85 enzymes of M. tuberculosis |
| Type | Fluorescent Probe |
| Relevance | The fluorescent Probe FITC-Trehalose is a fluorescent small-molecule probe to selectively label M. tuberculosis in culture and also in infected macrophages. |
| Molecular Formula | C34H36N2O15S |
| lUPAC | 1-Deoxy-α-D-gluco-hept-2-ulopyranosyl-(2→1)-2-deoxy-2-(N'-(fluorescein-5-yl)-thioureido)-α-D-glucopyranoside |
| Molecular Weight (g/mol) | 744.72 |
| In vivo applications | These compounds are incorporated into the cell envelope of mycobacteria, via the extracellular Ag85-enzymes, providing a means of detecting live organisms. These are the first small molecules that can be used to label and image tuberculosis in a selective manner in vivo. |
| Research Area | Bacteriology, Immunology |
References: 2 entries
Backus et al. 2011. Nat Chem Biol. 7(4):228-35. PMID: 21378984.
Uptake of unnatural trehalose analogs as a reporter for Mycobacterium tuberculosis.
Europe PMC ID: 21378984
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References: 2 entries
Backus et al. 2011. Nat Chem Biol. 7(4):228-35. PMID: 21378984.
Uptake of unnatural trehalose analogs as a reporter for Mycobacterium tuberculosis.
Add a reference
