Acute Traumatic Coagulopathy Rat
Invented at Queen Mary University of London
- Datasheet
- References (2)
- Inventor Info
Info
| Disease Keywords | Acute traumatic coagulopathy (ATC) |
| Relevance | The Acute Traumatic Coagulopathy Rat is a preclinical model of massive bleeding and hypovolemic shock to conduct translational and discovery research of coagulopathy and measure the impact of systemic inflammatory response to injury and cellular hypoxia in the context of organ dysfunction. Acute traumatic coagulopathy (ATC) is an impairment of hemostasis that occurs early after injury and is associated with a 4-fold higher mortality, increased transfusion requirements and organ failure. |
| Production Details | Rodent model of fixed-pressure haemorrhagic shock (90mins) |
| Conditional | No |
| Mouse Genetic Background/Cross History | Wistar rat |
| Research Area | Cardiovascular, Genetic Studies Tools |
References: 2 entries
Frith et al. 2010. J Thromb Haemost. 8(9):1919-25. PMID: 20553376.
Definition and drivers of acute traumatic coagulopathy: clinical and experimental investigations.
Europe PMC ID: 20553376
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References: 2 entries
Frith et al. 2010. J Thromb Haemost. 8(9):1919-25. PMID: 20553376.
Definition and drivers of acute traumatic coagulopathy: clinical and experimental investigations.
Add a reference
