Villin-Cre Apcfl/+ KRasG12D/+ Mouse
Invented at Cancer Research UK Glasgow: The Beatson Institute
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Info
| Catalogue Number | 152932 |
| Antigen/Gene or Protein Targets | KRasG12D |
| Disease Keywords | Colorectal cancer |
| Synonyms |
GTPase KRas K-Ras 2 Ki-Ras c-K-ras c-Ki-ras |
| Model | Mutant |
| Relevance | Oncogenic mutations in the K-ras gene occur in 50% of human colorectal cancers. However, the precise role that K-ras oncogenes play in tumor formation is still unclear. To address this issue, we have conditionally expressed an oncogenic K-rasD12 allele in the small intestine of adult mice either alone or in the context of Apc deficiency. |
| Conditional | Yes |
| Research Area | Cancer, Genetic Studies Tools |
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