Anti-CD19, Recombinant [BU12]
Invented at University Of Birmingham
- Datasheet
- References (1)
- Inventor Info
Info
| Catalogue Number | 153262 |
| Applications | FACS IHC IP |
| Antigen/Gene or Protein Targets | CD19 |
| Synonyms | CD19 Molecule; B-Lymphocyte Surface Antigen B4; T-Cell Surface Antigen Leu-12; Differentiation Antigen CD19; CD19 Antigen; CVID3; B4 |
| Reactivity | Human |
| Relevance | CD19 is a member of the immunoglobulin superfamily and has two Ig like domains. It is a single chain glycoprotein, present on the surface of normal and neoplastic B-cells. CD19 is expressed at an early stage by projenitor B-cells in bone marrow and during all stages of B-cell maturation. This antigen is lost upon terminal differentiation to plasma cells. CD19 is important for detecting both normal and neoplastic B-cells. CD19 is present on neoplasms arising from early B-cells (e.g. acute leukaemia of pre-B-cells) and more differentiated B-cell neoplasms (e.g. chronic Lymphocytic leukaemia and non-Hodgkin's lymphoma). Leukaemia phenotype studies have demonstrated that the earliest and broadest B cell restricted antigen is the CD19 antigen. The CD19 cytoplasmic domain binds tyrosine kinases and PI-3 kinase. |
| Host | Mouse |
| Immunogen | Human EB-4 Burkitt's lymphoma cell line |
| Subclass | IgG1 |
| Formulation | PBS |
| Concentration | 1mgml-1 |
| Research Area | Immunology |
| Notes |
Recombinant monoclonal antibody produced from the original monoclonal cell line. Manufactured using Absolute Antibody’s Recombinant Platform with variable regions (i.e. specificity) from the hybridoma. Five products based on this clone: - Anti-CD19 [BU12], Mouse IgG1, Kappa - Anti-CD19 [BU12], Rabbit IgG, Kappa - Anti-CD19 [BU12], Human IgG4-S228P, Kappa - Anti-CD19 [BU12], Human IgG1, Kappa - Anti-CD19 [BU12], Human IgG1, Kappa, engineered Fc domain containing key point mutations that abrogate binding to Fc gamma receptors. |
References: 1 entry
Original hybridoma first published in: Callard et al. 1992. J Immunol. 148(10):2983-7. PMID: 1374445.
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References: 1 entry
Original hybridoma first published in: Callard et al. 1992. J Immunol. 148(10):2983-7. PMID: 1374445.
Add a reference
