FH fl/fl Cell Line
Invented at Cancer Research UK Glasgow: The Beatson Institute
- Datasheet
- References (4)
- Inventor Info
Info
| Catalogue Number | 153291 |
| Antigen/Gene or Protein Targets | Fumarate Hydratase |
| Synonyms | Fumarate hydratase, FH, fumarase, Fh1, Hereditary leiomyomatosis and renal cell cancer, HLRCC |
| Host | Mouse |
| Tissue | Kidney |
| Disease Keywords | Cancer |
| Model | Conditional KO |
| Relevance | Fumarate hydratase – which can be found in either a mitochondrial or cytosolic form - is an enzyme that catalyzes the reversible hydration and dehydration of fumarate to malate. Signal sequences located in the protein dictate the subcellular location of each FH isoenzyme. The cytosolic form is involved in the metabolism of amino acids and fumarate and the mitochondrial form is involved in the Krebs Cycle (tricarboxylic acid cycle or the citric acid cycle). Germline mutations of FH are responsible for hereditary leiomyomatosis and renal-cell cancer (HLRCC)1. |
| Conditional | Yes |
| Conditional Description | Deletion of fumarate hydratase can be achieved by intracellular expression of Cre recombinase |
| Research Area | Cancer, Drug Discovery & Development, Metabolism |
| Cellosaurus ID | CVCL_HG00 |
References: 4 entries
Frezza et al. 2011. Nature. 477(7363):225-8. PMID: 21849978.
Haem oxygenase is synthetically lethal with the tumour suppressor fumarate hydratase.
Europe PMC ID: 21849978
Pollard et al. 2007. Cancer Cell. 11(4):311-9. PMID: 17418408.
Targeted inactivation of fh1 causes proliferative renal cyst development and activation of the hypoxia pathway.
Europe PMC ID: 17418408
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References: 4 entries
Frezza et al. 2011. Nature. 477(7363):225-8. PMID: 21849978.
Haem oxygenase is synthetically lethal with the tumour suppressor fumarate hydratase.
Pollard et al. 2007. Cancer Cell. 11(4):311-9. PMID: 17418408.
Targeted inactivation of fh1 causes proliferative renal cyst development and activation of the hypoxia pathway.
Add a reference
