Sdhb fl/fl Cell Line
Invented at Cancer Research UK Glasgow: The Beatson Institute
- Datasheet
- References (2)
- Inventor Info
Info
| Catalogue Number | 153294 |
| Antigen/Gene or Protein Targets | Succinate dehydrogenase |
| Synonyms | Succinate dehydrogenase, SDH, Succinate-coenzyme Q reductase, SQR |
| Host | Mouse |
| Tissue | Kidney |
| Disease Keywords | Cancer |
| Model | Conditional KO |
| Relevance | Succinate dehydrogenase (SDH) is an enzyme complex found in the inner mitochondrial membrane of mammalian mitochondria and many bacterial cells. SDH is the only enzyme that participates in both the electron transport chain and citric acid cycle. The enzymatic function of SDH oxidises succinate to fumarate in the tricarboxylic acid cycle and loosing this function is associated with cancer formation. |
| Conditional | Yes |
| Conditional Description | Deletion of succinate dehydrogenase can be achieved by intracellular expression of Cre recombinase |
| Research Area | Cancer, Drug Discovery & Development, Metabolism |
| Cellosaurus ID | CVCL_HG11 |
References: 2 entries
Cardaci et al. 2015. Nat Cell Biol. 17(10):1317-26. PMID: 26302408.
Pyruvate carboxylation enables growth of SDH-deficient cells by supporting aspartate biosynthesis.
Europe PMC ID: 26302408
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References: 2 entries
Cardaci et al. 2015. Nat Cell Biol. 17(10):1317-26. PMID: 26302408.
Pyruvate carboxylation enables growth of SDH-deficient cells by supporting aspartate biosynthesis.
Add a reference
