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ROCK2 Floxed Mouse

Invented at The Institute of Cancer Research
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Catalogue Number 153336
Antigen/Gene or Protein Targets Rho Associated Coiled-Coil Containing Protein Kinase 2
Synonyms ROCK2; Rho-associated protein kinase 2; Rho-associated, coiled-coil-containing protein kinase 2; ROCK-II
Model Transgenic
Relevance Rho associated coiled-coil containing protein kinases (ROCKs) exist in mammals, zebrafish, Xenopus, C. elegans and Drosophila. They are mainly involved in regulating the shape and movement of cells through acting on the cytoskeleton.

Two mouse ROCK isoforms ROCK1 and ROCK2 have been identified. ROCK1 is mainly expressed in the lung, liver, spleen, kidney and testis and ROCK2 is distributed mostly in the brain and heart. ROCK1 and ROCK2 are downstream effectors of the Rho subfamily of small GTPases, activated by Rho GTPases.

ROCK2, an isoenzyme of ROCK1, is a serine/threonine kinase and regulates cytokinesis, smooth muscle contraction, the formation of actin stress fibres and activation of the c-fos serum response element. ROCK1 is involved in cancer initiation and progression presumably through mechanisms related to metastasis, cell motility and angiogenesis.
Production Details Lox P sequences were inserted to flank exons 5 and 6 of the ROCK 2 gene
Breeding Information Mice are viable and have a normal lifespan
Conditional Yes
Conditional Description Requires expression of Cre recombinase to mediate excision of the lox P sites generating a non-functional ROCK 2 protein
Strain C57BL/6
Zygosity Homozygous
Research Area Cancer, Cell Cycle, Cell Structure and Motility, Cellular Transport, Developmental Biology

References

There are 2 reference entries for this reagent.

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References: 2 entries

Kümper et al. 2016. Elife. 5:e12994. PMID: 26765561.

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Rho-associated kinase (ROCK) function is essential for cell cycle progression, senescence and tumorigenesis.

Europe PMC ID: 26765561

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References: 2 entries

Kümper et al. 2016. Elife. 5:e12994. PMID: 26765561.

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Rho-associated kinase (ROCK) function is essential for cell cycle progression, senescence and tumorigenesis.

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Inventor Information

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Invented at

The Institute of Cancer Research
The Institute of Cancer Research

35 reagents listed on Ximbio