Anti-Plakoglobin, Polyclonal [VB3]
Invented by Prof Fiona Watt from King's College London
Invented at Cancer Research UK London Research Institute: Lincoln's Inn Fields
- Datasheet
- References (10)
- Inventor Info
Info
| Catalogue Number | 153350 |
| Applications | IF IP WB |
| Antigen/Gene or Protein Targets | Plakoglobin |
| Synonyms | Gamma Catenin |
| Reactivity | Human and Mouse |
| Relevance | Plakoglobin is a common junctional plaque protein. The membrane-associated plaques are architectural elements in an important strategic position to influence the arrangement and function of both the cytoskeleton and the cells within the tissue. The presence of plakoglobin in both the desmosomes and in the intermediate junctions suggests that it plays a central role in the structure and function of submembranous plaques. Acts as a substrate for VE-PTP and is required by it to stimulate VE-cadherin function in endothelial cells. Can replace beta-catenin in E-cadherin/catenin adhesion complexes which are proposed to couple cadherins to the actin cytoskeleton. |
| Host | Rabbit |
| Immunogen | Peptide - NH2-CIDTYSDGLRPPYPTADH-COOH |
| Formulation | Serum |
| Positive Control | A431 or HaCaT cell lysate |
| Research Area | Adhesion |
References: 10 entries
Erasmus et al. 2016. Nat Commun. 7:13542. PMID: 27922008.
IF
Defining functional interactions during biogenesis of epithelial junctions.
Europe PMC ID: 27922008
Ryan et al. 2012. J Cell Sci. 125(Pt 13):3202-9. PMID: 22454524.
WB
Plakoglobin-dependent regulation of keratinocyte apoptosis by Rnd3.
Europe PMC ID: 22454524
Zhu et al. 1999. Development. 126(10):2285-98. PMID: 10207152.
WB
beta-catenin signalling modulates proliferative potential of human epidermal keratinocytes independently of intercellular adhesion.
Europe PMC ID: 10207152
Braga et al. 1995. Cell Adhes Commun. 3(3):201-15. PMID: 8846022.
IF WB
Calcium-induced changes in distribution and solubility of cadherins, integrins and their associated cytoplasmic proteins in human keratinocytes.
Europe PMC ID: 8846022
Näthke et al. 1994. J Cell Biol. 125(6):1341-52. PMID: 8207062.
IP
Defining interactions and distributions of cadherin and catenin complexes in polarized epithelial cells.
Europe PMC ID: 8207062
Add a reference
References: 10 entries
Erasmus et al. 2016. Nat Commun. 7:13542. PMID: 27922008.
IF
Defining functional interactions during biogenesis of epithelial junctions.
Ryan et al. 2012. J Cell Sci. 125(Pt 13):3202-9. PMID: 22454524.
WB
Plakoglobin-dependent regulation of keratinocyte apoptosis by Rnd3.
Zhu et al. 1999. Development. 126(10):2285-98. PMID: 10207152.
WB
beta-catenin signalling modulates proliferative potential of human epidermal keratinocytes independently of intercellular adhesion.
Braga et al. 1995. Cell Adhes Commun. 3(3):201-15. PMID: 8846022.
IF WB
Calcium-induced changes in distribution and solubility of cadherins, integrins and their associated cytoplasmic proteins in human keratinocytes.
Näthke et al. 1994. J Cell Biol. 125(6):1341-52. PMID: 8207062.
IP
Defining interactions and distributions of cadherin and catenin complexes in polarized epithelial cells.
Add a reference
