Anti-CD151, Recombinant [11G5a]
Invented at University of Manchester
- Datasheet
- References (1)
- Inventor Info
Info
| Catalogue Number | 153364 |
| Applications | ELISA FACS IHC IF IP WB |
| Antigen/Gene or Protein Targets | CD151 (PETA-3) |
| Synonyms | CD151 Molecule (Raph Blood Group); Platelet-Endothelial Tetraspan Antigen; CD151 Antigen (Raph Blood Group); Membrane Glycoprotein SFA-1; Tetraspanin-24; CD151 Antigen; Tspan-24; TSPAN24; PETA-3 |
| Reactivity | Human |
| Relevance | Clone 11G5a recognizes the human CD151 cell surface antigen, also known as PETA-3. CD151 is expressed by epithelial cells, endothelial cells, platelets, megakaryocytes, monocytes and in the renal glomeruli and proximal and distal tubules. CD151 is not expressed by lymphocytes or granulocytes. More recently CD151 has also been shown to be expressed by erythrocytes, and to carry the MER2 blood group antigen. CD151 is a cell surface glycoprote involved in cellular processes including cell adhesion and may regulate integrin trafficking and/or function. This protein enhances cell motility, invasion and metastasis of cancer cells. |
| Host | Mouse |
| Subclass | IgG1 |
| Formulation | PBS |
| Concentration | 1mg/ml |
| Research Area | Adhesion, Cancer, Cardiovascular, Cell Signaling & Signal Transduction, Cell Structure and Motility, Immunology |
| Notes |
CD151 is very closely associated with the alpha3 beta1 integrin in cells and co-immunoprecipitation may occur even in quite stringent conditions (Yauch. et al. 1998). For staining of paraffin section antigen retrieval through heat treatment with Sodium citrate buffer pH 6.0 is recommended. Recombinant monoclonal antibody produced from the original monoclonal. Manufactured using Absolute Antibody’s Recombinant Platform with variable regions (i.e. specificity) from the hybridoma. |
References: 1 entry
Original hybridoma first published in: Yauch et al. 1998. Mol Biol Cell. 9(10):2751-65. PMID: 9763442.
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References: 1 entry
Original hybridoma first published in: Yauch et al. 1998. Mol Biol Cell. 9(10):2751-65. PMID: 9763442.
Add a reference
