H157 Cell Line
Invented at University Of Bristol
- Datasheet
- References (8)
- Inventor Info
Info
| Catalogue Number | 153420 |
| Antigen/Gene or Protein Targets | Human oral squamous cell carcinoma |
| Tissue | Buccal mucosa |
| Disease Keywords | Cancer |
| Model | Tumour line |
| Relevance | Established from a squamous cell carcinoma (SCC) of the buccal mucosa (20mm-40mm) of a male patient, age 84. STNMP stage II, well differentiated, node positive tumour. Mutant p53, codon 306 exon 8, G to A; wild type K-, N- and Ha-ras. Non-tumourigenic in athymic nude mice by subcutaneous injection and on injection into the floor of the mouth (orthotopic), but form epidermoid cysts subcutaneously |
| Research Area | Cancer |
| Growth/Phenotype Keywords | Adherent |
| Recommended Growing Conditions | Split sub-confluent cultures (70-80%) 1:8 to 1:10 5% CO2; 37°C. Suggested seeding density 5 x 1000 cells/cm². DMEM:HAMS F12 (1:1) + 2mM Glutamine + 10% Foetal Bovine Serum (FBS) + 0.5 ug/ml sodium hydrocortisone succinate. |
| Cellosaurus ID | CVCL_2458 |
References: 8 entries
Yeudall et al. 1995. Eur J Cancer B Oral Oncol. 31B(2):136-43. PMID: 7633286.
Presence of human papillomavirus sequences in tumour-derived human oral keratinocytes expressing mutant p53.
Europe PMC ID: 7633286
Prime et al. 1994. Br J Cancer. 69(1):8-15. PMID: 8286215.
Epidermal growth factor and transforming growth factor alpha characteristics of human oral carcinoma cell lines.
Europe PMC ID: 8286215
Yeudall et al. 1993. Eur J Cancer B Oral Oncol. 29B(1):63-7. PMID: 8180579.
Ras gene point mutation is a rare event in premalignant tissues and malignant cells and tissues from oral mucosal lesions.
Europe PMC ID: 8180579
Prime et al. 1990. J Pathol. 160(3):259-69. PMID: 1692339.
The behaviour of human oral squamous cell carcinoma in cell culture.
Europe PMC ID: 1692339
Add a reference
References: 8 entries
Yeudall et al. 1995. Eur J Cancer B Oral Oncol. 31B(2):136-43. PMID: 7633286.
Presence of human papillomavirus sequences in tumour-derived human oral keratinocytes expressing mutant p53.
Prime et al. 1994. Br J Cancer. 69(1):8-15. PMID: 8286215.
Epidermal growth factor and transforming growth factor alpha characteristics of human oral carcinoma cell lines.
Yeudall et al. 1993. Eur J Cancer B Oral Oncol. 29B(1):63-7. PMID: 8180579.
Ras gene point mutation is a rare event in premalignant tissues and malignant cells and tissues from oral mucosal lesions.
Prime et al. 1990. J Pathol. 160(3):259-69. PMID: 1692339.
The behaviour of human oral squamous cell carcinoma in cell culture.
Add a reference
