Family 1 mother - LAD-III Lymphoblastoid Cell Line
Invented by Prof Nancy Hogg from Cancer Research UK London Research Institute: Lincoln's Inn Fields
Invented at Cancer Research UK London Research Institute: Lincoln's Inn Fields
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- References (2)
- Inventor Info
Info
| Catalogue Number | 153764 |
| Antigen/Gene or Protein Targets | Kindlin-3, UniProt ID:Q86UX7 |
| Synonyms | Fermitin family homolog 3, MIG2-like protein, Unc-112-related protein 2 |
| Host | Human |
| Disease Keywords | Leukocyte Adhesion Deficiency-III (LAD-III) |
| Relevance | An EBV-transformed B lymphoblastoid cell line (LCL) derived from the mother of a Maltese subject that has Leukocyte Adhesion Deficiency-III (LAD-III) with a mutation in the kindlin-3 gene. LCLs are also available from the subject, father and subject's sister. This cell line was derived from 'Family 1 mother' as described in Svensson et al. 2009. N.Nat Med. 2009 Mar;15(3):306-12. PMID: 1923446 |
| Research Area | Adhesion, Cardiovascular, Immunology |
| Growth/Phenotype Keywords | Suspension, lymphoblastoid cell line |
| Recommended Growing Conditions | RPMI-1640 + 10% FCS |
References: 2 entries
Svensson et al. 2009. Nat Med. 15(3):306-12. PMID: 19234463.
Leukocyte adhesion deficiency-III is caused by mutations in KINDLIN3 affecting integrin activation.
Europe PMC ID: 19234463
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References: 2 entries
Svensson et al. 2009. Nat Med. 15(3):306-12. PMID: 19234463.
Leukocyte adhesion deficiency-III is caused by mutations in KINDLIN3 affecting integrin activation.
Add a reference
