Anti-CEP164 [1F3G10]
Invented by Prof Ciaran Morrison from National University of Ireland, Galway
Invented at National University of Ireland, Galway , Centre For Chromosome Biology
- Datasheet
- References (7)
- Inventor Info
Info
| Catalogue Number | 153780 |
| Applications | IHC IF IP WB |
| Antigen/Gene or Protein Targets | Anti-CEP164 [1F3G10] |
| Synonyms | Centrosomal protein of 164 kDa, KIAA1052, NPHP15 |
| Reactivity | Human |
| Relevance | CEP164 plays a role in microtubule organization and/or maintenance for the formation of primary cilia (PC), a microtubule-based structure that protrudes from the surface of epithelial cells. Plays a critical role in G2/M checkpoint and nuclear divisions. A key player in the DNA damage-activated ATR/ATM signaling cascade since it is required for the proper phosphorylation of H2AX, RPA, CHEK2 and CHEK1. Plays a critical role in chromosome segregation, acting as a mediator required for the maintenance of genomic stability through modulation of MDC1, RPA and CHEK1. |
| Host | Mouse |
| Immunogen | Recombinant human CEP164 amino acids 6-296 (bacterially expressed from pGEX4T as a GST fusion, then thrombin-cleaved and purified). |
| Positive Control | hTERT-RPE1 Cell Line |
| Subclass | IgG1 kappa |
| Molecular Weight (kDa) | 164 kDa (runs c.190) |
| Myeloma Used | Sp2/0-Ag14 |
| Notes | Staining pattern: Centriole distal appendages (mother centriole-specific) |
| Research Area | Cancer, Cell Cycle, Cell Structure and Motility, Metabolism |
References: 7 entries
Flynn et al. 2020. Hum Mol Genet. 29(3):407-417. PMID: 31868218.
IF
Khouj et al. 2019. J Cell Sci. 132(19):. PMID: 31492759.
IF
Sieben et al. 2018. Nat Methods. 15(10):777-780. PMID: 30275574.
Multicolor single-particle reconstruction of protein complexes.
Europe PMC ID: 30275574
Ogungbenro et al. 2018. J Cell Biol. 217(4):1205-1215. PMID: 29440264.
IF
Daly et al. 2016. J Cell Sci. 129(9):1769-74. PMID: 26966185.
IF
CEP164-null cells generated by genome editing show a ciliation defect with intact DNA repair capacity.
Europe PMC ID: 26966185
Add a reference
References: 7 entries
Flynn et al. 2020. Hum Mol Genet. 29(3):407-417. PMID: 31868218.
IF
Khouj et al. 2019. J Cell Sci. 132(19):. PMID: 31492759.
IF
Sieben et al. 2018. Nat Methods. 15(10):777-780. PMID: 30275574.
Multicolor single-particle reconstruction of protein complexes.
Ogungbenro et al. 2018. J Cell Biol. 217(4):1205-1215. PMID: 29440264.
IF
Daly et al. 2016. J Cell Sci. 129(9):1769-74. PMID: 26966185.
IF
CEP164-null cells generated by genome editing show a ciliation defect with intact DNA repair capacity.
Add a reference
