GST-3X-TDP43_106-175 (DELTARRM1) Vector
Invented by Prof Emanuele Buratti from International Centre For Genetic Engineering And Biotechnology (ICGEB)
Invented at International Centre For Genetic Engineering And Biotechnology (ICGEB)
- Datasheet
- References (2)
- Inventor Info
Info
| Catalogue Number | 153791 |
| Backbone Size (bp) | 4900 |
| Bacterial Resistance | Ampicillin |
| Vector Type | pGEX |
| Synonyms | TARDBP, TAR DNA Binding Protein, TDP-43, TAR DNA-Binding Protein 43, ALS10 |
| Antigen/Gene or Protein Targets | TDP43 lacking RRM1 |
| Relevance | The TAR DNA-binding protein (TDP-43) is a highly conserved heterogeneous nuclear ribonucleoprotein (hnRNP) that controls the transcription, splicing and RNA stability of specific genes. The protein associates with single-stranded RNA and DNA sequences, and exhibits remarkable specificity for UG/TG dinucleotide repeats. Regulation of the human low-molecular-weight neurofilament (hNFL) by TDP-43 has also been reported to occur through 3′ UTR recruitment. TDP-43 is the major protein in inclusions from patients suffering from frontotemporal lobar degeneration (FTLD) with ubiquitin-positive inclusions and amyotrophic lateral sclerosis (ALS). This is a mutant version of TDP-43 that lacks the RRM1 domain and does not bind RNA |
| Research Area | Gene Expression, Neurobiology, Virology |
| Notes | Concentration 1mg/ml |
References: 2 entries
Buratti et al. 2001. J Biol Chem. 276(39):36337-43. PMID: 11470789.
Characterization and functional implications of the RNA binding properties of nuclear factor TDP-43, a novel splicing regulator of CFTR exon 9.
Europe PMC ID: 11470789
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References: 2 entries
Buratti et al. 2001. J Biol Chem. 276(39):36337-43. PMID: 11470789.
Characterization and functional implications of the RNA binding properties of nuclear factor TDP-43, a novel splicing regulator of CFTR exon 9.
Add a reference
