Oct1/2 Knock Out Mouse
Invented at Netherlands Cancer Institute
- Datasheet
- References (4)
- Inventor Info
Info
| Catalogue Number | 153874 |
| Antigen/Gene or Protein Targets | Oct1 and Oct2 |
| Synonyms | SLC22A1/2, Solute Carrier Family 22 Member 1/2, Organic Cation Transporter 1/2 |
| Model | Knock-Out |
| Relevance | Oct1/2 are polyspecific organic cation transporters in the liver, kidney, intestine, and other organs. They are critical for elimination of many endogenous small organic cations as well as a wide array of drugs and environmental toxins |
| Production Details | The model was created through sequential targeting of the Slc22a1 and Slc22a2 genes in 129/Ola-derived E14 ES cells and injecting the targeted cells into C57BL/6 blastocysts. Resultant chimeras were backcrossed to FVB/N for seven generations |
| Breeding Information | The colony is maintained by mating doubly homozygous mic |
| Conditional | No |
| Mouse Genetic Background/Cross History | FVB Background |
| Zygosity | Homozygous |
| Research Area | Cancer, Cell Signaling & Signal Transduction, Drug Discovery & Development |
| Notes |
Useful for studies of drug transport in the liver, intestine and kidneys. OCT1 and OCT2 determine renal secretion of small organic cations. The Oct1/2 mouse was developed in the laboratory of Alfred Schinkel of the Netherlands Cancer Institute |
References: 4 entries
Jonker et al. 2003. Mol Cell Biol. 23(21):7902-8. PMID: 14560032.
Deficiency in the organic cation transporters 1 and 2 (Oct1/Oct2 [Slc22a1/Slc22a2]) in mice abolishes renal secretion of organic cations.
Europe PMC ID: 14560032
Jonker et al. 2001. Mol Cell Biol. 21(16):5471-7. PMID: 11463829.
Reduced hepatic uptake and intestinal excretion of organic cations in mice with a targeted disruption of the organic cation transporter 1 (Oct1 [Slc22a1]) gene.
Europe PMC ID: 11463829
Add a reference
References: 4 entries
Jonker et al. 2003. Mol Cell Biol. 23(21):7902-8. PMID: 14560032.
Deficiency in the organic cation transporters 1 and 2 (Oct1/Oct2 [Slc22a1/Slc22a2]) in mice abolishes renal secretion of organic cations.
Jonker et al. 2001. Mol Cell Biol. 21(16):5471-7. PMID: 11463829.
Reduced hepatic uptake and intestinal excretion of organic cations in mice with a targeted disruption of the organic cation transporter 1 (Oct1 [Slc22a1]) gene.
Add a reference
