Anti-SUMO-2/SUMO-3 (8A2) antibody
Invented at Johns Hopkins University
- Datasheet
- References (2)
- Inventor Info
Info
| Catalogue Number | 153986 |
| Applications | ChIP IHC IF IP WB |
| Antigen/Gene or Protein Targets | SUMO-2 and SUMO-3 but does not recognize SUMO-1 |
| Synonyms | Small ubiquitin-related modifier 2; HSMT3; SMT3 homolog 2; SUMO-3; Zentrin-2; Ubiquitin-like protein SMT3B; Smt3B |
| Reactivity | Human |
| Relevance | Small ubiquitin-like modifiers (SUMO) post-translationally modify proteins by a process called SUMOylation. There are three SUMO proteins expressed in vertebrates, SUMO-2 and SUMO-3 are ~95% identical to each other (SUMO-2/3), but they are only ~45% identical to SUMO-1. Consequently, SUMO-2/3 have unique targets and functions compared to SUMO-1. For instances SUMO-2/3 can form polymeric chains and SUMO-1 cannot. SUMOylation on lysine residues regulates various cellular processes including nuclear transport, DNA replication and repair, transcription, protein stability, mitochondrial fission, signal transduction, mitosis and apoptosis. |
| Host | Mouse |
| Immunogen | Full length human recombinant protein of SUMO-2 |
| Subclass | IgG |
| Research Area | Apoptosis and Programmed Cell Death, Cell Cycle, Cell Signaling & Signal Transduction, DNA Damage and Repair, Protein Degradation |
References: 2 entries
Zhang et al. 2008. Mol Cell. 29(6):729-41. PMID: 18374647.
SUMO-2/3 modification and binding regulate the association of CENP-E with kinetochores and progression through mitosis.
Europe PMC ID: 18374647
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References: 2 entries
Zhang et al. 2008. Mol Cell. 29(6):729-41. PMID: 18374647.
SUMO-2/3 modification and binding regulate the association of CENP-E with kinetochores and progression through mitosis.
Add a reference
