Anti-phospho Sam68, Ser113/117, Polyclonal Antibody
Invented at Johns Hopkins University
- Datasheet
- References (2)
- Inventor Info
Info
| Catalogue Number | 153988 |
| Applications | IHC WB |
| Antigen/Gene or Protein Targets | Sam68 (Src-associated during mitosis, 68 kDa) |
| Synonyms | KH domain-containing, RNA-binding, signal transduction-associated protein 1, GAP-associated tyrosine phosphoprotein p62, Src-associated in mitosis 68 kDa protein, p21 Ras GTPase-activating protein-associated p62, p68 |
| Reactivity | Human, Mouse and Rat |
| Relevance | Sam68 (KHDRBS1 also known as KH domain-containing, RNA-binding, signal transduction-associated protein 1) is a RNA binding protein that binds to U(U/A)AA direct repeats to regulate RNA splicing, transcription, RNA metabolism, signal transduction, the cell cycle and apoptosis. Post-translational modifications on Sam68 is what allows it to regulate many different cellular process. For instance, when Sam68 is phosphorylated, on serine 113 and 117, it forms nuclear factor-kappaB (NF-κB) complexes and binds to promoters of genomic targets important for human lymphocyte activation. |
| Host | Rabbit |
| Immunogen | Synthetic peptide (NH2-CAEKD(Sp)LDP(Sp)FTH-COOH) |
| Molecular Weight (kDa) | 68 kDa |
| Research Area | Apoptosis and Programmed Cell Death, Cell Cycle, Cell Signaling & Signal Transduction, Gene Expression |
References: 2 entries
Fu et al. 2013. Nat Commun. 4:1909. PMID: 23715268.
Sam68 modulates the promoter specificity of NF-κB and mediates expression of CD25 in activated T cells.
Europe PMC ID: 23715268
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References: 2 entries
Fu et al. 2013. Nat Commun. 4:1909. PMID: 23715268.
Sam68 modulates the promoter specificity of NF-κB and mediates expression of CD25 in activated T cells.
Add a reference
