Anti-Omentin [3G1B3]
Invented at University Of Maryland
- Datasheet
- References (2)
- Inventor Info
Info
| Catalogue Number | 153990 |
| Applications | IP WB |
| Antigen/Gene or Protein Targets | Omentin |
| Synonyms | Intelectin-1, ITLN1, hIntL-1 |
| Reactivity | Human, Mouse and Rat |
| Relevance |
Monoclonal antibody which detects omentin, linked to diabetes. Background and Research Application Omentin (human intelectin-1) is a secreted glycoprotein involved in the innate immune system as well as enhancing insulin-stimulated glucose uptake. Highly expressed in small intestine and adipose tissue and present at lower levels in testis, heart, pancreas, colon and skeletal muscle, intelectin-1 exists as a disulphide-linked homotrimer that functions to enhance insulin-stimulated glucose uptake and is also thought to participate in host defence against microorganisms. Serum levels of omentin are negatively correlated with obesity, suggesting a role in diabetes. More recently, omentin has been shown to interact with glycans on pathogenic bacteria. |
| Host | Mouse |
| Immunogen | recombinant omentin |
| Immunogen UniProt ID | Q8WWA0 |
| Subclass | IgG |
| Molecular Weight (kDa) | 120 kDa (trimer), 37 kDa (monomer) |
| Notes |
Production Details Purified using multi-step affinity chromatography with protein A. Storage Conditions Store at -20 degrees frozen. Avoid repeated freeze/thaw cycles. Points of Interest Having conserved ligand binding site residues, both human and mouse intelectin-1 bind the exocyclic vicinal diol of carbohydrate ligands such as galactofuranose. Concentration 1mg/ml as standard |
| Research Area | Bacteriology, Cardiovascular, Immunology, Metabolism, Microbiology |
References: 2 entries
Yang et al. 2006. Am J Physiol Endocrinol Metab. 290(6):E1253-61. PMID: 16531507.
Identification of omentin as a novel depot-specific adipokine in human adipose tissue: possible role in modulating insulin action.
Europe PMC ID: 16531507
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References: 2 entries
Yang et al. 2006. Am J Physiol Endocrinol Metab. 290(6):E1253-61. PMID: 16531507.
Identification of omentin as a novel depot-specific adipokine in human adipose tissue: possible role in modulating insulin action.
Add a reference
