Anti Ovarian Cancer Cells [A4] Monoclonal Antibody
Invented by Andre Choo
Invented at A*STAR Accelerate Technologies Pte Ltd
- Datasheet
- References (1)
- Inventor Info
Info
| Catalogue Number | 154116 |
| Applications | N/A |
| Antigen/Gene or Protein Targets | Human Embryonic Stem Cells, Ovarian Cancer Cells, Breast Cancer Cells |
| Synonyms | Anti-hESC [A4], Anti-OC [A4], Anti-Breast Cancer Cells [A4] |
| Reactivity | Human |
| Host | Mouse |
| Immunogen | HES-3 (Human Embryonic Stem cell line) |
| Subclass | IgM |
| Notes |
Monoclonal antibody mAb-A4 against human embryonic stem cells (hESC), which also bound specifically to N-glycans present on 11 of 19 ovarian cancer (OC) and 8 of 14 breast cancer cell lines tested. Normal cell lines and tissue were unstained by mAb-A4. The mAb-A4 epitopes were found to be Fucα1–2Galβ1–3GlcNAcβ (H type 1) and Galβ1–3GlcNAcβ (type 1 LacNAc). These structures were found to be present on multiple proteins from hESC and OC. The recognition of oncofetal H type 1 and type 1 LacNAc on OC by mAb-A4 is a novel and promising way to target OC and supports the theory that cancer can acquire stem-like phenotypes. It is proposed that that the orthogonal framework used in this work could be the basis for advancing anti-glycan mAb characterization. |
| Research Area | Cancer |
References: 1 entry
References: 1 entry
Inventor Information
Inventors
|
Andre Choo |
