Anti-CD79a [HM57] recombinant antibody
Invented at University of Oxford
- Datasheet
- References (10)
- Inventor Info
Info
| Catalogue Number | 154817 |
| Antigen/Gene or Protein Targets | CD79a (mb1) |
| Synonyms | CD79a Molecule; Membrane-Bound Immunoglobulin-Associated Protein; Surface IgM-Associated Protein; MB-1 Membrane Glycoprotein; Ig-Alpha; IGA; CD79a Antigen; MB1 |
| Reactivity | Bovine, Chicken, Horse, Human, Guinea Pig, Mouse, Opossum, Pig, Primate, Rat and Rabbit |
| Relevance | The B-cell Antigen receptor constitutes a disulphide linked heterodimer, consisting of CD79a (mb1) and CD79b / B29 polypeptides which are non-covalently associated with membrane bound immunoglobulins on B-cells. CD79a first appears at pre B-cell stage and persists until the plasma cell stage where it is found as an intracellular component. CD79a is found in B-cell lymphomas, in B-cell lines, the majority of acute leukemias of precursor B-cell type and in some myelomas. The CD79a/b heterodimer interacts with at least one tyrosine kinase (Lyn). The induction of tyrosine kinase activity after antigen binding leads to phosphorylation of the CD79a/b dimer, and also of other molecules, thereby initiating intracellular signalling. CD79a is widely used as an adjunct to CD20 as a biomarker for normal and neoplastic B-cells in tissues sections. |
| Host | Mouse |
| Immunogen | Synthetic peptide of 14 amino acids representing residues 202-216 of the human mb-1 cDNA sequence. |
| Subclass | IgG1 |
| Research Area | Cancer, Cell Signaling & Signal Transduction, Immunology, Stem Cell Biology |
References: 10 entries
CD79a: a novel marker for B-cell neoplasms in routinely processed tissue samples.
Detection of T and B cells in many animal species using cross-reactive anti-peptide antibodies.
Jones et al. 1993. J Immunol. 150(12):5429-35. PMID: 8515069.
Mason et al. 1991. J Immunol. 147(11):2474-82. PMID: 1747162.
Mason et al. 1992. Eur J Immunol. 22(10):2753-6. PMID: 1396979.
Mason et al. 1995. Blood. 86(4):1453-9. PMID: 7632952.
The B29 and mb-1 polypeptides are differentially expressed during human B cell differentiation.
The IgM-associated protein mb-1 as a marker of normal and neoplastic B cells.
The membrane IgM-associated heterodimer on human B cells is a newly defined B cell antigen that contains the protein product of the mb-1 gene.
van Noesel et al. 1991. J Immunol. 146(11):3881-8. PMID: 2033258.
Add a reference
References: 10 entries
CD79a: a novel marker for B-cell neoplasms in routinely processed tissue samples.
Detection of T and B cells in many animal species using cross-reactive anti-peptide antibodies.
Jones et al. 1993. J Immunol. 150(12):5429-35. PMID: 8515069.
Mason et al. 1991. J Immunol. 147(11):2474-82. PMID: 1747162.
Mason et al. 1992. Eur J Immunol. 22(10):2753-6. PMID: 1396979.
Mason et al. 1995. Blood. 86(4):1453-9. PMID: 7632952.
The B29 and mb-1 polypeptides are differentially expressed during human B cell differentiation.
The IgM-associated protein mb-1 as a marker of normal and neoplastic B cells.
The membrane IgM-associated heterodimer on human B cells is a newly defined B cell antigen that contains the protein product of the mb-1 gene.
van Noesel et al. 1991. J Immunol. 146(11):3881-8. PMID: 2033258.
Add a reference
