Anti-IE of b,k,r,s,v [Y17] monoclonal antibody
Invented at Yale University
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- Inventor Info
Info
| Catalogue Number | 155238 |
| Applications | N/A |
| Antigen/Gene or Protein Targets | IE |
| Reactivity | N/A |
| Relevance |
Monoclonal antibody which can inhibit T cell response to Ae:E alpha determinants. Background and Research Application This antibody is directed at a conformational or combinatorial determinant formed by certain Ae:E alpha complexes. This marker is found upon a subset of B cells as well as on non-T and non-B spleen cells. Antibody Y-17 can inhibit the response of T cells to Ae:E alpha determinants in mixed lymphocyte cultures. Furthermore, Y-17 inhibits the antigen-induced T cell proliferative response to GLPhe and pigeon cytochrome c; responses which are under dual-Ir-gene control and correlate with the expression of certain A~:E~ complexes on antigen-presenting cell surfaces. |
| Immunogen UniProt ID | P04223 |
| Subclass | IgG2b |
| Notes |
Production Details Purified using multi-step affinity chromatography with protein A. Storage Conditions Store at -20 degrees frozen. Avoid repeated freeze/thaw cycles. Points of Interest Besides Ae and E alpha chains, Y-17 precipitates a third chain that is indistinguishable from the A alpha chain in two-dimensional gels. Concentration 1mg/ml as standard |
| Research Area | Immunology |
